Expression of a phosphorylated p130^Cas substrate domain attenuates the phosphatidylinositol 3-kinase/Akt survival pathway in tamoxifen resistant breast cancer cells

Biochemistry, Genetics and Molecular Biology

• Bcl-2 50%
• Cancer Cell 100%
• Cell Death 50%
• Downregulation 50%
• Growth Factor Signaling 50%
• Morphology 50%
• Overall Survival 50%
• Peptide 50%
• Phosphoinositide 3-Kinase 100%
• Programmed Cell Death 100%
• Protein Kinase B 100%
• Revertant 50%
• Signal Transduction 50%
• Small Interfering RNA 50%

Keyphrases

• Anti-apoptotic Bcl-2 10%
• Antiestrogen 10%
• Apoptosis 10%
• Apoptosis Induction 10%
• Attenuation 10%
• Breast Cancer 10%
• Breast Cancer Cells 100%
• Cell Death 10%
• Dominant Negative 10%
• Elevated Levels 10%
• Epithelial Phenotype 10%
• Estrogen 10%
• Growth Factor Signaling 10%
• Human Breast Tumor 10%
• Knockdown 10%
• Long-term Exposure 10%
• MCF-7 Cells 10%
• Morphological Changes 10%
• Overall Survival 10%
• P130Cas 100%
• Phosphoinositide 3-kinase/Akt Pathway 10%
• Poor Prognosis 10%
• Resistant Breast Cancer 10%
• Signal Transduction 10%
• Small Interfering RNA (siRNA) 10%
• Survival Pathways 100%
• Tamoxifen Resistance 10%
• Tamoxifen Therapy 10%