TY - JOUR
T1 - Expression of adiponectin and its receptors in avian species
AU - Ramachandran, Ramesh
AU - Maddineni, Sreenivasa
AU - Ocón-Grove, Olga
AU - Hendricks, Gilbert
AU - Vasilatos-Younken, Regina
AU - Hadley, Jill A.
N1 - Funding Information:
This project was supported in part by National Research Initiative Competitive Grant No. 2007-35206-17905 from the USDA Cooperative State Research, Education, and Extension Service and by Agriculture and Food Research Initiative Competitive Grant No. 2012-67015-30193 from the USDA National Institute of Food and Agriculture.
PY - 2012/6/5
Y1 - 2012/6/5
N2 - Adipose tissue is a dynamic endocrine organ secreting a variety of hormones that affect physiological functions within the central nervous system, cardiovascular system, reproductive, and immune systems. The endocrine role of avian adipose tissue remains enigmatic as many of the classical hormones found in mammalian adipose tissue have not been found in avians. This mini-review summarizes our current knowledge on avian adiponectin, one of the most abundant adipose tissue hormones, and its receptors. We cloned the genes encoding chicken adiponectin and its receptors, AdipoR1 and AdipoR2. Using anti-chicken adiponectin antibody, we found that chicken adipose tissue and plasma predominantly contain a unique polymer of adiponectin with a mass greater than 669. kDa, unlike mammalian adiponectin which is found as three distinct oligomers. Mass spectrometric analyses of chicken adiponectin revealed certain post-translational modifications that are likely to favor the unique multimerization of adiponectin in chickens. Unlike adiponectin, the nucleotide sequences of chicken AdipoR1- and AdipoR2 cDNA are highly similar to that of mammalian adiponectin receptors. Both adiponectin and adiponectin receptors are widely expressed in several tissues in the chicken. Herein, we review the unique biochemistry of adiponectin as well as expression of adiponectin and its receptors in the chicken. Future studies should focus on elucidating the role of adiponectin, AdipoR1, and AdipoR2 on metabolism, steroidogenesis, and adipose tissue remodeling during growth and reproduction in birds.
AB - Adipose tissue is a dynamic endocrine organ secreting a variety of hormones that affect physiological functions within the central nervous system, cardiovascular system, reproductive, and immune systems. The endocrine role of avian adipose tissue remains enigmatic as many of the classical hormones found in mammalian adipose tissue have not been found in avians. This mini-review summarizes our current knowledge on avian adiponectin, one of the most abundant adipose tissue hormones, and its receptors. We cloned the genes encoding chicken adiponectin and its receptors, AdipoR1 and AdipoR2. Using anti-chicken adiponectin antibody, we found that chicken adipose tissue and plasma predominantly contain a unique polymer of adiponectin with a mass greater than 669. kDa, unlike mammalian adiponectin which is found as three distinct oligomers. Mass spectrometric analyses of chicken adiponectin revealed certain post-translational modifications that are likely to favor the unique multimerization of adiponectin in chickens. Unlike adiponectin, the nucleotide sequences of chicken AdipoR1- and AdipoR2 cDNA are highly similar to that of mammalian adiponectin receptors. Both adiponectin and adiponectin receptors are widely expressed in several tissues in the chicken. Herein, we review the unique biochemistry of adiponectin as well as expression of adiponectin and its receptors in the chicken. Future studies should focus on elucidating the role of adiponectin, AdipoR1, and AdipoR2 on metabolism, steroidogenesis, and adipose tissue remodeling during growth and reproduction in birds.
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U2 - 10.1016/j.ygcen.2013.05.004
DO - 10.1016/j.ygcen.2013.05.004
M3 - Review article
C2 - 23707376
AN - SCOPUS:84882876016
SN - 0016-6480
VL - 190
SP - 88
EP - 95
JO - General and Comparative Endocrinology
JF - General and Comparative Endocrinology
ER -