Expression of Dlx genes during the development of the murine dentition

Zhiyong Zhao, David W. Stock, Anne V. Buchanan, Kenneth M. Weiss

Research output: Contribution to journalArticlepeer-review

74 Scopus citations


The mammalian Dlx homeobox gene family has been shown to play multiple roles in tooth development, but a detailed comparison of the expression pattern of all members throughout tooth development has been lacking. We provide such an analysis for the six known murine Dlx genes. The expression patterns for these genes allow a refinement of previously proposed models for the role of Dlx genes in tooth type specification and raise the possibility of roles for subsets of these genes in tooth initiation, morphogenesis (enamel navel formation, enamel knot induction, cervical loop growth), and enamel formation. The relationship of Dlx gene expression to their genomic organization suggests coordinate regulation of linked genes at early stages but regulatory differences at later stages.

Original languageEnglish (US)
Pages (from-to)270-275
Number of pages6
JournalDevelopment Genes and Evolution
Issue number5
StatePublished - 2000

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology


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