Expression of HLA system antigens on placenta

P. N. Goodfellow, C. J. Barnstable, W. F. Bodmer, D. Snary, M. J. Crumpton

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139 Scopus citations


The levels of HLA-A and -B antigens expressed by placenta have been assessed relative to parental and other A and B antigen types that were not shared by the foetus. A purified preparation of placenta plasma membrane was used to estimate the antigen activities. The results indicate that maternally and paternally inherited A and B antigen activities and ß2-microglobulin are expressed to similar extents but at much lower levels than in spleen lymphocytes (less than 5%). The possibility that the amounts detected were caused by contamination with blood or maternal tissue was ruled out. The low levels of A and B antigens may account for the lack of a cellular immune response to the other polymorphic cell surface antigens of the trophoblast. No evidence was obtained for the expression of a significant level of Ia antigens.

Original languageEnglish (US)
Pages (from-to)595-603
Number of pages9
Issue number6
StatePublished - Dec 1976

All Science Journal Classification (ASJC) codes

  • Transplantation


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