Expression of Immunomodulator Gene mRNA in Co-Culture of Mesenchymal Stromal Cells from the Placenta and Human Mononuclear Blood Cells

A. M. Savilova; M. M. Chulkina; V. N. Veryasov; M. N. Gordeeva; D. Yu Trofimov; G. T. Sukhikh

doi:10.1007/s10517-015-2807-y

Expression of Immunomodulator Gene mRNA in Co-Culture of Mesenchymal Stromal Cells from the Placenta and Human Mononuclear Blood Cells

A. M. Savilova, M. M. Chulkina, V. N. Veryasov, M. N. Gordeeva, D. Yu Trofimov, G. T. Sukhikh

Department of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The expression of mRNA of cytokines and immunoregulatory molecules characterizing the interaction of mesenchymal stromal cells from chorionic villi of postpartum placenta and allogenic mononuclear blood cells was studied during 3-day co-culturing of these cells. The expression of foxp3, il2ra, and il10 mRNA in floating mononuclear cells increased from day 1 to 3 in co-culture, which can refl ect the process of induction of regulatory T cells in the lymphocyte population under the action of mesenchymal stromal cells.

Original language	English (US)
Pages (from-to)	561-565
Number of pages	5
Journal	Bulletin of Experimental Biology and Medicine
Volume	158
Issue number	4
DOIs	https://doi.org/10.1007/s10517-015-2807-y
State	Published - Feb 1 2015

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

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title = "Expression of Immunomodulator Gene mRNA in Co-Culture of Mesenchymal Stromal Cells from the Placenta and Human Mononuclear Blood Cells",

abstract = "The expression of mRNA of cytokines and immunoregulatory molecules characterizing the interaction of mesenchymal stromal cells from chorionic villi of postpartum placenta and allogenic mononuclear blood cells was studied during 3-day co-culturing of these cells. The expression of foxp3, il2ra, and il10 mRNA in floating mononuclear cells increased from day 1 to 3 in co-culture, which can refl ect the process of induction of regulatory T cells in the lymphocyte population under the action of mesenchymal stromal cells.",

author = "Savilova, \{A. M.\} and Chulkina, \{M. M.\} and Veryasov, \{V. N.\} and Gordeeva, \{M. N.\} and Trofimov, \{D. Yu\} and Sukhikh, \{G. T.\}",

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doi = "10.1007/s10517-015-2807-y",

language = "English (US)",

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T1 - Expression of Immunomodulator Gene mRNA in Co-Culture of Mesenchymal Stromal Cells from the Placenta and Human Mononuclear Blood Cells

AU - Savilova, A. M.

AU - Chulkina, M. M.

AU - Veryasov, V. N.

AU - Gordeeva, M. N.

AU - Trofimov, D. Yu

AU - Sukhikh, G. T.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - The expression of mRNA of cytokines and immunoregulatory molecules characterizing the interaction of mesenchymal stromal cells from chorionic villi of postpartum placenta and allogenic mononuclear blood cells was studied during 3-day co-culturing of these cells. The expression of foxp3, il2ra, and il10 mRNA in floating mononuclear cells increased from day 1 to 3 in co-culture, which can refl ect the process of induction of regulatory T cells in the lymphocyte population under the action of mesenchymal stromal cells.

AB - The expression of mRNA of cytokines and immunoregulatory molecules characterizing the interaction of mesenchymal stromal cells from chorionic villi of postpartum placenta and allogenic mononuclear blood cells was studied during 3-day co-culturing of these cells. The expression of foxp3, il2ra, and il10 mRNA in floating mononuclear cells increased from day 1 to 3 in co-culture, which can refl ect the process of induction of regulatory T cells in the lymphocyte population under the action of mesenchymal stromal cells.

UR - https://www.scopus.com/pages/publications/84952715343

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U2 - 10.1007/s10517-015-2807-y

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SN - 0007-4888

VL - 158

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JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

IS - 4

ER -

Expression of Immunomodulator Gene mRNA in Co-Culture of Mesenchymal Stromal Cells from the Placenta and Human Mononuclear Blood Cells

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