TY - JOUR
T1 - Expression of S100 protein in CD4-positive T-cell lymphomas is often associated with T-cell prolymphocytic leukemia
AU - Aggarwal, Nidhi
AU - Pongpruttipan, Tawatchai
AU - Patel, Snehal
AU - Bayerl, Michael
AU - Alkan, Serhan
AU - Nathwani, Bharat
AU - Surti, Urvashi
AU - Kitahara, Sumire
AU - Chinthammitr, Yingyong
AU - Swerdlow, Steven H.
N1 - Publisher Copyright:
© 2015 Wolters Kluwer Health, Inc.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - S100 + T-cell lymphomas are infrequent, and except 1 all have been CD4 negative. On the basis of an index case of CD4 + S100 + T-cell prolymphocytic leukemia (T-PLL), we studied S100 protein expression in 19 additional T-PLLs and 56 other T-cell lymphomas that are usually CD4 +, including 15 angioimmunoblastic T-cell lymphomas, 24 anaplastic large cell lymphomas (16 ALK + and 8 ALK -), 7 mycosis fungoides/Sézary syndrome, and 10 peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS). Two additional S100 + CD4 + PTCL, NOS cases were also reviewed. Thirty percent (6/20) of T-PLLs were S100 + compared with 0/56 other T-cell lymphomas with previously unstudied S100 reactivity (40 CD4 +, 2 CD8 +, 11 CD4 - /CD8 -, 3 unknown) (P=0.0007). There were no significant differences between the S100 + and S100 - T-PLLs with regard to the male:female ratio (2:1 vs. 1:1), age (71.6±7.7 vs. 65.4±9.3), peripheral blood lymphocyte count (67.2±116.6 vs. 101.1±159.7×10 9 /L), or median survival (463 vs. 578 d, where known). The 2 S100 + PTCL, NOS cases occurred in a 7-year-old boy and a 45-year-old woman. Both had involvement of the bone marrow and peripheral blood but were morphologically unlike T-PLL and lacked TCL1 gene rearrangement. These results demonstrate that S100 + T-cell lymphomas include a subset that are CD4 + and most often, but not exclusively, are T-PLL. Although having diagnostic implications, there were no documented clinical differences between the S100 + and S100 - T-PLLs.
AB - S100 + T-cell lymphomas are infrequent, and except 1 all have been CD4 negative. On the basis of an index case of CD4 + S100 + T-cell prolymphocytic leukemia (T-PLL), we studied S100 protein expression in 19 additional T-PLLs and 56 other T-cell lymphomas that are usually CD4 +, including 15 angioimmunoblastic T-cell lymphomas, 24 anaplastic large cell lymphomas (16 ALK + and 8 ALK -), 7 mycosis fungoides/Sézary syndrome, and 10 peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS). Two additional S100 + CD4 + PTCL, NOS cases were also reviewed. Thirty percent (6/20) of T-PLLs were S100 + compared with 0/56 other T-cell lymphomas with previously unstudied S100 reactivity (40 CD4 +, 2 CD8 +, 11 CD4 - /CD8 -, 3 unknown) (P=0.0007). There were no significant differences between the S100 + and S100 - T-PLLs with regard to the male:female ratio (2:1 vs. 1:1), age (71.6±7.7 vs. 65.4±9.3), peripheral blood lymphocyte count (67.2±116.6 vs. 101.1±159.7×10 9 /L), or median survival (463 vs. 578 d, where known). The 2 S100 + PTCL, NOS cases occurred in a 7-year-old boy and a 45-year-old woman. Both had involvement of the bone marrow and peripheral blood but were morphologically unlike T-PLL and lacked TCL1 gene rearrangement. These results demonstrate that S100 + T-cell lymphomas include a subset that are CD4 + and most often, but not exclusively, are T-PLL. Although having diagnostic implications, there were no documented clinical differences between the S100 + and S100 - T-PLLs.
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U2 - 10.1097/PAS.0000000000000496
DO - 10.1097/PAS.0000000000000496
M3 - Article
C2 - 26379148
AN - SCOPUS:84948716238
SN - 0147-5185
VL - 39
SP - 1679
EP - 1687
JO - American Journal of Surgical Pathology
JF - American Journal of Surgical Pathology
IS - 12
ER -