TY - GEN
T1 - External electric field effect on the PR neuronal firing under the ephaptic transmission
AU - Wei, Xile
AU - Chen, Yinhong
AU - Wang, Jiang
AU - Deng, Bin
AU - Lu, Meili
AU - Che, Yanqiu
PY - 2011
Y1 - 2011
N2 - The external electric field (EF) has shown to have great influence on neurons. On account of the effects of applied fields on neural activity through the induced EF in the extracellular medium, the electrical characteristics of the extracellular medium should not be ignored for accurately reflecting the biological field effect. Here considering the electrical characteristic of extracellular medium i.e. ephaptic transmission, neuronal firing is studied based on a PR neuron model in the presence of the external (EF), including direct current (DC) and alternating current (AC) EF. Moreover, three key parameters (the inner conductance g c, the inverted potential of potassium ion V K and the extracellular resistance between dendrite and soma R out DS), which are crucial for the dynamics of neurons, are introduced to develop the neuronal firing. Different firing rhythms of neuron imply different stimulus information, and in some particular stimulus frequency the synchronization between the firing rhythm and EF signal is observed.
AB - The external electric field (EF) has shown to have great influence on neurons. On account of the effects of applied fields on neural activity through the induced EF in the extracellular medium, the electrical characteristics of the extracellular medium should not be ignored for accurately reflecting the biological field effect. Here considering the electrical characteristic of extracellular medium i.e. ephaptic transmission, neuronal firing is studied based on a PR neuron model in the presence of the external (EF), including direct current (DC) and alternating current (AC) EF. Moreover, three key parameters (the inner conductance g c, the inverted potential of potassium ion V K and the extracellular resistance between dendrite and soma R out DS), which are crucial for the dynamics of neurons, are introduced to develop the neuronal firing. Different firing rhythms of neuron imply different stimulus information, and in some particular stimulus frequency the synchronization between the firing rhythm and EF signal is observed.
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U2 - 10.1109/BMEI.2011.6098722
DO - 10.1109/BMEI.2011.6098722
M3 - Conference contribution
AN - SCOPUS:84862937342
SN - 9781424493524
T3 - Proceedings - 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011
SP - 1839
EP - 1843
BT - Proceedings - 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011
T2 - 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011
Y2 - 15 October 2011 through 17 October 2011
ER -