TY - JOUR
T1 - Eyelid dermatitis in patients referred for patch testing
T2 - Retrospective analysis of North American Contact Dermatitis Group data, 1994-2016
AU - Warshaw, Erin M.
AU - Voller, Lindsey M.
AU - Maibach, Howard I.
AU - Zug, Kathryn A.
AU - DeKoven, Joel G.
AU - Atwater, Amber R.
AU - Reeder, Margo J.
AU - Sasseville, Denis
AU - Taylor, James S.
AU - Fowler, Joseph F.
AU - Pratt, Melanie D.
AU - Silverberg, Jonathan I.
AU - Fransway, Anthony F.
AU - Zirwas, Matthew J.
AU - Belsito, Donald V.
AU - Marks, James G.
AU - DeLeo, Vincent A.
N1 - Funding Information:
Conflicts of interest: Dr Atwater received a Pfizer Independent Grant for Learning & Change and serves as a consultant for Henkel. Dr. Warshaw has received a research grant from and served as a consultant for Wen by Chaz Dean. Drs Maibach, Zug, DeKoven, Reeder, Sasseville, Taylor, Fowler, Pratt, Silverberg, Fransway, Zirwas, Belsito, Marks, Mathias, and DeLeo and Ms. Voller have no conflicts of interest to declare.
Publisher Copyright:
© 2020
PY - 2021/4
Y1 - 2021/4
N2 - Background: Eyelid dermatitis is a common dermatologic complaint. Objective: To characterize patients with eyelid dermatitis. Methods: Retrospective analysis (1994-2016) of North American Contact Dermatitis Group data. Results: Of 50,795 patients, 2332 (4.6%) had eyelid dermatitis only, whereas 1623 (3.2%) also had dermatitis of the eyelids and head or neck. Compared with patients without eyelid involvement (n = 26,130), groups with eyelid dermatitis only and dermatitis of the eyelid and head or neck were significantly more likely to be female, white, and older than 40 years, and to have a history of hay fever, atopic dermatitis, or both (P <.01). Final primary diagnoses included allergic contact dermatitis (eyelid dermatitis only: 43.4%; dermatitis of the eyelid and head or neck: 53.5%), irritant contact dermatitis (eyelid dermatitis only: 17.0%; dermatitis of the eyelid and head or neck: 9.8%), and atopic dermatitis (eyelid dermatitis only: 13.1%; dermatitis of the eyelid and head or neck: 13.8%). Top 5 currently relevant allergens included nickel sulfate (eyelid dermatitis only: 18.6%; dermatitis of the eyelid and head or neck: 22.5%), fragrance mix I (eyelid dermatitis only: 16.5%; dermatitis of the eyelid and head or neck: 18.3%), methylisothiazolinone (eyelid dermatitis only: 16.5%; dermatitis of the eyelid and head or neck: 17.7%), gold sodium thiosulfate (eyelid dermatitis only: 14.7%; dermatitis of the eyelid and head or neck: 11.4%), and balsam of Peru (eyelid dermatitis only: 11.9%; dermatitis of the eyelid and head or neck: 12.6%). Both eyelid-involvement groups were significantly more likely to react to gold sodium thiosulfate, carmine, shellac, dimethylaminopropylamine, oleamidopropyl dimethylamine, and thimerosal (P <.05) compared with the no eyelid involvement group. Limitations: Lack of specific distribution patterns of eyelid dermatitis and no long-term follow-up data. Conclusion: Patch testing remains a critical tool in evaluating patients with eyelid dermatitis.
AB - Background: Eyelid dermatitis is a common dermatologic complaint. Objective: To characterize patients with eyelid dermatitis. Methods: Retrospective analysis (1994-2016) of North American Contact Dermatitis Group data. Results: Of 50,795 patients, 2332 (4.6%) had eyelid dermatitis only, whereas 1623 (3.2%) also had dermatitis of the eyelids and head or neck. Compared with patients without eyelid involvement (n = 26,130), groups with eyelid dermatitis only and dermatitis of the eyelid and head or neck were significantly more likely to be female, white, and older than 40 years, and to have a history of hay fever, atopic dermatitis, or both (P <.01). Final primary diagnoses included allergic contact dermatitis (eyelid dermatitis only: 43.4%; dermatitis of the eyelid and head or neck: 53.5%), irritant contact dermatitis (eyelid dermatitis only: 17.0%; dermatitis of the eyelid and head or neck: 9.8%), and atopic dermatitis (eyelid dermatitis only: 13.1%; dermatitis of the eyelid and head or neck: 13.8%). Top 5 currently relevant allergens included nickel sulfate (eyelid dermatitis only: 18.6%; dermatitis of the eyelid and head or neck: 22.5%), fragrance mix I (eyelid dermatitis only: 16.5%; dermatitis of the eyelid and head or neck: 18.3%), methylisothiazolinone (eyelid dermatitis only: 16.5%; dermatitis of the eyelid and head or neck: 17.7%), gold sodium thiosulfate (eyelid dermatitis only: 14.7%; dermatitis of the eyelid and head or neck: 11.4%), and balsam of Peru (eyelid dermatitis only: 11.9%; dermatitis of the eyelid and head or neck: 12.6%). Both eyelid-involvement groups were significantly more likely to react to gold sodium thiosulfate, carmine, shellac, dimethylaminopropylamine, oleamidopropyl dimethylamine, and thimerosal (P <.05) compared with the no eyelid involvement group. Limitations: Lack of specific distribution patterns of eyelid dermatitis and no long-term follow-up data. Conclusion: Patch testing remains a critical tool in evaluating patients with eyelid dermatitis.
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U2 - 10.1016/j.jaad.2020.07.020
DO - 10.1016/j.jaad.2020.07.020
M3 - Article
C2 - 32679276
AN - SCOPUS:85101202794
SN - 0190-9622
VL - 84
SP - 953
EP - 964
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 4
ER -