TY - JOUR
T1 - Eyelid dermatitis in patients referred for patch testing
T2 - Retrospective analysis of North American Contact Dermatitis Group data, 1994-2016
AU - Warshaw, Erin M.
AU - Voller, Lindsey M.
AU - Maibach, Howard I.
AU - Zug, Kathryn A.
AU - DeKoven, Joel G.
AU - Atwater, Amber R.
AU - Reeder, Margo J.
AU - Sasseville, Denis
AU - Taylor, James S.
AU - Fowler, Joseph F.
AU - Pratt, Melanie D.
AU - Silverberg, Jonathan I.
AU - Fransway, Anthony F.
AU - Zirwas, Matthew J.
AU - Belsito, Donald V.
AU - Marks, James G.
AU - DeLeo, Vincent A.
N1 - Publisher Copyright:
© 2020
PY - 2021/4
Y1 - 2021/4
N2 - Background: Eyelid dermatitis is a common dermatologic complaint. Objective: To characterize patients with eyelid dermatitis. Methods: Retrospective analysis (1994-2016) of North American Contact Dermatitis Group data. Results: Of 50,795 patients, 2332 (4.6%) had eyelid dermatitis only, whereas 1623 (3.2%) also had dermatitis of the eyelids and head or neck. Compared with patients without eyelid involvement (n = 26,130), groups with eyelid dermatitis only and dermatitis of the eyelid and head or neck were significantly more likely to be female, white, and older than 40 years, and to have a history of hay fever, atopic dermatitis, or both (P <.01). Final primary diagnoses included allergic contact dermatitis (eyelid dermatitis only: 43.4%; dermatitis of the eyelid and head or neck: 53.5%), irritant contact dermatitis (eyelid dermatitis only: 17.0%; dermatitis of the eyelid and head or neck: 9.8%), and atopic dermatitis (eyelid dermatitis only: 13.1%; dermatitis of the eyelid and head or neck: 13.8%). Top 5 currently relevant allergens included nickel sulfate (eyelid dermatitis only: 18.6%; dermatitis of the eyelid and head or neck: 22.5%), fragrance mix I (eyelid dermatitis only: 16.5%; dermatitis of the eyelid and head or neck: 18.3%), methylisothiazolinone (eyelid dermatitis only: 16.5%; dermatitis of the eyelid and head or neck: 17.7%), gold sodium thiosulfate (eyelid dermatitis only: 14.7%; dermatitis of the eyelid and head or neck: 11.4%), and balsam of Peru (eyelid dermatitis only: 11.9%; dermatitis of the eyelid and head or neck: 12.6%). Both eyelid-involvement groups were significantly more likely to react to gold sodium thiosulfate, carmine, shellac, dimethylaminopropylamine, oleamidopropyl dimethylamine, and thimerosal (P <.05) compared with the no eyelid involvement group. Limitations: Lack of specific distribution patterns of eyelid dermatitis and no long-term follow-up data. Conclusion: Patch testing remains a critical tool in evaluating patients with eyelid dermatitis.
AB - Background: Eyelid dermatitis is a common dermatologic complaint. Objective: To characterize patients with eyelid dermatitis. Methods: Retrospective analysis (1994-2016) of North American Contact Dermatitis Group data. Results: Of 50,795 patients, 2332 (4.6%) had eyelid dermatitis only, whereas 1623 (3.2%) also had dermatitis of the eyelids and head or neck. Compared with patients without eyelid involvement (n = 26,130), groups with eyelid dermatitis only and dermatitis of the eyelid and head or neck were significantly more likely to be female, white, and older than 40 years, and to have a history of hay fever, atopic dermatitis, or both (P <.01). Final primary diagnoses included allergic contact dermatitis (eyelid dermatitis only: 43.4%; dermatitis of the eyelid and head or neck: 53.5%), irritant contact dermatitis (eyelid dermatitis only: 17.0%; dermatitis of the eyelid and head or neck: 9.8%), and atopic dermatitis (eyelid dermatitis only: 13.1%; dermatitis of the eyelid and head or neck: 13.8%). Top 5 currently relevant allergens included nickel sulfate (eyelid dermatitis only: 18.6%; dermatitis of the eyelid and head or neck: 22.5%), fragrance mix I (eyelid dermatitis only: 16.5%; dermatitis of the eyelid and head or neck: 18.3%), methylisothiazolinone (eyelid dermatitis only: 16.5%; dermatitis of the eyelid and head or neck: 17.7%), gold sodium thiosulfate (eyelid dermatitis only: 14.7%; dermatitis of the eyelid and head or neck: 11.4%), and balsam of Peru (eyelid dermatitis only: 11.9%; dermatitis of the eyelid and head or neck: 12.6%). Both eyelid-involvement groups were significantly more likely to react to gold sodium thiosulfate, carmine, shellac, dimethylaminopropylamine, oleamidopropyl dimethylamine, and thimerosal (P <.05) compared with the no eyelid involvement group. Limitations: Lack of specific distribution patterns of eyelid dermatitis and no long-term follow-up data. Conclusion: Patch testing remains a critical tool in evaluating patients with eyelid dermatitis.
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U2 - 10.1016/j.jaad.2020.07.020
DO - 10.1016/j.jaad.2020.07.020
M3 - Article
C2 - 32679276
AN - SCOPUS:85101202794
SN - 0190-9622
VL - 84
SP - 953
EP - 964
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 4
ER -