TY - JOUR
T1 - F-18 FDG PET/CT imaging of endogenous cushing syndrome
AU - Jackson, Tatianie A.
AU - Choong, Karen W.
AU - Eng, Jessica A.
AU - McAneny, David
AU - Subramaniam, Rathan M.
AU - Knapp, Philip E.
PY - 2011/12
Y1 - 2011/12
N2 - Cushing syndrome (CS) is a rare condition, with an incidence of 2 to 4 cases per million inhabitants per year. In most cases of CS, elevated adrenocorticotropic hormone (ACTH) secretion results in excess adrenal gland cortisol secretion but usually this is from pituitary, not ectopic ACTH production. We present a case of a 52-year-old woman with lower extremity edema and weakness. Physical examination revealed alopecia, hyperpigmentation, acne, and a 4-cm right thyroid mass with lymphadenopathy. Biopsy revealed medullary thyroid carcinoma (MTC). She was also diagnosed with CS caused by ectopic ACTH production, presumably from the MTC. PET/CT showed a large mass within the right lobe of the thyroid gland, extensive metastatic disease and bilateral adrenal gland hypertrophy due to CS which initially raised concern for adrenal metastases.
AB - Cushing syndrome (CS) is a rare condition, with an incidence of 2 to 4 cases per million inhabitants per year. In most cases of CS, elevated adrenocorticotropic hormone (ACTH) secretion results in excess adrenal gland cortisol secretion but usually this is from pituitary, not ectopic ACTH production. We present a case of a 52-year-old woman with lower extremity edema and weakness. Physical examination revealed alopecia, hyperpigmentation, acne, and a 4-cm right thyroid mass with lymphadenopathy. Biopsy revealed medullary thyroid carcinoma (MTC). She was also diagnosed with CS caused by ectopic ACTH production, presumably from the MTC. PET/CT showed a large mass within the right lobe of the thyroid gland, extensive metastatic disease and bilateral adrenal gland hypertrophy due to CS which initially raised concern for adrenal metastases.
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U2 - 10.1097/RLU.0b013e3182336360
DO - 10.1097/RLU.0b013e3182336360
M3 - Article
C2 - 22064119
AN - SCOPUS:80955136523
SN - 0363-9762
VL - 36
SP - e231-e232
JO - Clinical nuclear medicine
JF - Clinical nuclear medicine
IS - 12
ER -