Fabrication and characterization of baghdadite nanostructured scaffolds by space holder method

Sorour Sadeghzade, Fateme Shamoradi, Rahmatollah Emadi, Fariborz Tavangarian

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Porous baghdadite scaffold has received great attention as a candidate for bone tissue engineering application due to its remarkable bioactivity, biocompatibility, and good bone formation ability. A few studies have been focused on improving the mechanical properties of baghdadite scaffolds. Recently, space holder method has been introduced as a new and viable technique to prepare bioceramic scaffolds with interconnected pores and suitable mechanical properties. In this study, for the first time, 3D baghdadite scaffolds with interconnected porosity were produced using space holder method. X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) were utilized to characterize various specimens. The baghdadite scaffolds were sintered at various temperatures in the range of 1250–1350 °C for 3 h. The compressive strength and compressive modulus measured to be in the range of 0.05–0.52 MPa and 2.1–121.5 MPa, respectively. The results showed that nanostructured baghdadite scaffolds with a crystallite size of about 32 nm, 75% porosity and pores size in the range of 200–500 µm can be successfully fabricated after sintering at 1350 °C for 3 h. Simulated body fluid (SBF) was used to evaluate the apatite formation ability of the scaffolds. The results showed the formation of an apatite layer on the scaffold surface which can be considered as a bioactivity criterion.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalJournal of the Mechanical Behavior of Biomedical Materials
StatePublished - Apr 1 2017

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering
  • Mechanics of Materials


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