Failure to replicate a QTL association between a DNA marker identified by EST00083 and IQ

Stephen A. Petrill; David Ball; Thalia Eley; Linzy Hill; Robert Plomin; Gerald E. Mcclearn; Deborah L. Smith; Karen Chorney; Michael Chorney; Milton S. Hershz; Douglas K. Detterman; Lee A. Thompson; Camilla Benbow; David Lubinski; Johanna Daniels; Michael J. Owen; Peter McGuffin

doi:10.1016/S0160-2896(97)90041-6

Failure to replicate a QTL association between a DNA marker identified by EST00083 and IQ

Stephen A. Petrill, David Ball, Thalia Eley, Linzy Hill, Robert Plomin, Gerald E. Mcclearn, Deborah L. Smith, Karen Chorney, Michael Chorney, Milton S. Hershz, Douglas K. Detterman, Lee A. Thompson, Camilla Benbow, David Lubinski, Johanna Daniels, Michael J. Owen, Peter McGuffin

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14 Scopus citations

Abstract

In a paper published in this journal, a possible QTL association was reported between general cognitive ability and a marker, identified by an expressed sequence tag, EST00083 (Skuder et al., 1995). In two small samples, the frequency of the common allele of this DNA marker, which was shown to be in the threonine transfer RNA gene in mitochondrial DNA, was significantly greater in a high-IQ group than in a low-IQ group. As part of the ongoing IQ QTL Project (Plomin et al., 1995), we have attempted to replicate this QTL association. First, we found that the QTL association remained significant when we compared 51 high- and 51 -average IQ subjects, drawn in part from the samples used in the previous report. However, when we examined the association in new samples of 40 extremely high-IQ subjects and 50 average-IQ subjects, the association did not replicate. This underlies the need for replication in case-control studies of allelic association.

Original language	English (US)
Pages (from-to)	179-184
Number of pages	6
Journal	Intelligence
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/S0160-2896(97)90041-6
State	Published - 1997

All Science Journal Classification (ASJC) codes

Experimental and Cognitive Psychology
Developmental and Educational Psychology
Arts and Humanities (miscellaneous)

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10.1016/S0160-2896(97)90041-6

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Petrill, S. A., Ball, D., Eley, T., Hill, L., Plomin, R., Mcclearn, G. E., Smith, D. L., Chorney, K., Chorney, M., Hershz, M. S., Detterman, D. K., Thompson, L. A., Benbow, C., Lubinski, D., Daniels, J., Owen, M. J., & McGuffin, P. (1997). Failure to replicate a QTL association between a DNA marker identified by EST00083 and IQ. Intelligence, 25(3), 179-184. https://doi.org/10.1016/S0160-2896(97)90041-6

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title = "Failure to replicate a QTL association between a DNA marker identified by EST00083 and IQ",

abstract = "In a paper published in this journal, a possible QTL association was reported between general cognitive ability and a marker, identified by an expressed sequence tag, EST00083 (Skuder et al., 1995). In two small samples, the frequency of the common allele of this DNA marker, which was shown to be in the threonine transfer RNA gene in mitochondrial DNA, was significantly greater in a high-IQ group than in a low-IQ group. As part of the ongoing IQ QTL Project (Plomin et al., 1995), we have attempted to replicate this QTL association. First, we found that the QTL association remained significant when we compared 51 high- and 51 -average IQ subjects, drawn in part from the samples used in the previous report. However, when we examined the association in new samples of 40 extremely high-IQ subjects and 50 average-IQ subjects, the association did not replicate. This underlies the need for replication in case-control studies of allelic association.",

author = "Petrill, {Stephen A.} and David Ball and Thalia Eley and Linzy Hill and Robert Plomin and Mcclearn, {Gerald E.} and Smith, {Deborah L.} and Karen Chorney and Michael Chorney and Hershz, {Milton S.} and Detterman, {Douglas K.} and Thompson, {Lee A.} and Camilla Benbow and David Lubinski and Johanna Daniels and Owen, {Michael J.} and Peter McGuffin",

year = "1997",

doi = "10.1016/S0160-2896(97)90041-6",

language = "English (US)",

volume = "25",

pages = "179--184",

journal = "Intelligence",

issn = "0160-2896",

publisher = "Elsevier Limited",

number = "3",

}

Petrill, SA, Ball, D, Eley, T, Hill, L, Plomin, R, Mcclearn, GE, Smith, DL, Chorney, K, Chorney, M, Hershz, MS, Detterman, DK, Thompson, LA, Benbow, C, Lubinski, D, Daniels, J, Owen, MJ & McGuffin, P 1997, 'Failure to replicate a QTL association between a DNA marker identified by EST00083 and IQ', Intelligence, vol. 25, no. 3, pp. 179-184. https://doi.org/10.1016/S0160-2896(97)90041-6

TY - JOUR

T1 - Failure to replicate a QTL association between a DNA marker identified by EST00083 and IQ

AU - Petrill, Stephen A.

AU - Ball, David

AU - Eley, Thalia

AU - Hill, Linzy

AU - Plomin, Robert

AU - Mcclearn, Gerald E.

AU - Smith, Deborah L.

AU - Chorney, Karen

AU - Chorney, Michael

AU - Hershz, Milton S.

AU - Detterman, Douglas K.

AU - Thompson, Lee A.

AU - Benbow, Camilla

AU - Lubinski, David

AU - Daniels, Johanna

AU - Owen, Michael J.

AU - McGuffin, Peter

PY - 1997

Y1 - 1997

N2 - In a paper published in this journal, a possible QTL association was reported between general cognitive ability and a marker, identified by an expressed sequence tag, EST00083 (Skuder et al., 1995). In two small samples, the frequency of the common allele of this DNA marker, which was shown to be in the threonine transfer RNA gene in mitochondrial DNA, was significantly greater in a high-IQ group than in a low-IQ group. As part of the ongoing IQ QTL Project (Plomin et al., 1995), we have attempted to replicate this QTL association. First, we found that the QTL association remained significant when we compared 51 high- and 51 -average IQ subjects, drawn in part from the samples used in the previous report. However, when we examined the association in new samples of 40 extremely high-IQ subjects and 50 average-IQ subjects, the association did not replicate. This underlies the need for replication in case-control studies of allelic association.

AB - In a paper published in this journal, a possible QTL association was reported between general cognitive ability and a marker, identified by an expressed sequence tag, EST00083 (Skuder et al., 1995). In two small samples, the frequency of the common allele of this DNA marker, which was shown to be in the threonine transfer RNA gene in mitochondrial DNA, was significantly greater in a high-IQ group than in a low-IQ group. As part of the ongoing IQ QTL Project (Plomin et al., 1995), we have attempted to replicate this QTL association. First, we found that the QTL association remained significant when we compared 51 high- and 51 -average IQ subjects, drawn in part from the samples used in the previous report. However, when we examined the association in new samples of 40 extremely high-IQ subjects and 50 average-IQ subjects, the association did not replicate. This underlies the need for replication in case-control studies of allelic association.

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DO - 10.1016/S0160-2896(97)90041-6

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SN - 0160-2896

VL - 25

SP - 179

EP - 184

JO - Intelligence

JF - Intelligence

IS - 3

ER -

Failure to replicate a QTL association between a DNA marker identified by EST00083 and IQ

Abstract

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