False-positive PET/CT for lymphoma recurrence secondary to Langerhans cell histiocytosis.

Joseph S. Fotos; Donald J. Flemming; Mark Tulchinsky

doi:10.1097/rlu.0b013e318219ad60

False-positive PET/CT for lymphoma recurrence secondary to Langerhans cell histiocytosis.

Joseph S. Fotos, Donald J. Flemming, Mark Tulchinsky

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Abstract

A 28-year-old man with a history of Hodgkin lymphoma that was intensely [F-18]fluoro-2-deoxy-D-glucose-avid at diagnosis had achieved complete remission following appropriate therapy. On surveillance positron emission tomography/computed tomography (CT), new, intensely [F-18]fluoro-2-deoxy-D-glucose-avid lesions (lytic on CT) were seen within the vertebral body of C7, left scapula, and right glenoid. The findings of a biopsy revealed these lesions to be Langerhans cell histiocytosis. Langerhans cell histiocytosis arising in the context of lymphoma is a well-documented phenomenon, and its appearance on positron emission tomography/CT cannot be conclusively distinguished from lymphoma recurrence. This manuscript emphasizes the necessity of biopsy to ensure correct diagnosis and subsequent correct therapy.

Original language	English (US)
Pages (from-to)	717-719
Number of pages	3
Journal	Clinical nuclear medicine
Volume	36
Issue number	8
DOIs	https://doi.org/10.1097/rlu.0b013e318219ad60
State	Published - Aug 2011

All Science Journal Classification (ASJC) codes

Radiology Nuclear Medicine and imaging

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10.1097/rlu.0b013e318219ad60

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title = "False-positive PET/CT for lymphoma recurrence secondary to Langerhans cell histiocytosis.",

abstract = "A 28-year-old man with a history of Hodgkin lymphoma that was intensely [F-18]fluoro-2-deoxy-D-glucose-avid at diagnosis had achieved complete remission following appropriate therapy. On surveillance positron emission tomography/computed tomography (CT), new, intensely [F-18]fluoro-2-deoxy-D-glucose-avid lesions (lytic on CT) were seen within the vertebral body of C7, left scapula, and right glenoid. The findings of a biopsy revealed these lesions to be Langerhans cell histiocytosis. Langerhans cell histiocytosis arising in the context of lymphoma is a well-documented phenomenon, and its appearance on positron emission tomography/CT cannot be conclusively distinguished from lymphoma recurrence. This manuscript emphasizes the necessity of biopsy to ensure correct diagnosis and subsequent correct therapy.",

author = "Fotos, {Joseph S.} and Flemming, {Donald J.} and Mark Tulchinsky",

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AU - Fotos, Joseph S.

AU - Flemming, Donald J.

AU - Tulchinsky, Mark

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PY - 2011/8

Y1 - 2011/8

N2 - A 28-year-old man with a history of Hodgkin lymphoma that was intensely [F-18]fluoro-2-deoxy-D-glucose-avid at diagnosis had achieved complete remission following appropriate therapy. On surveillance positron emission tomography/computed tomography (CT), new, intensely [F-18]fluoro-2-deoxy-D-glucose-avid lesions (lytic on CT) were seen within the vertebral body of C7, left scapula, and right glenoid. The findings of a biopsy revealed these lesions to be Langerhans cell histiocytosis. Langerhans cell histiocytosis arising in the context of lymphoma is a well-documented phenomenon, and its appearance on positron emission tomography/CT cannot be conclusively distinguished from lymphoma recurrence. This manuscript emphasizes the necessity of biopsy to ensure correct diagnosis and subsequent correct therapy.

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False-positive PET/CT for lymphoma recurrence secondary to Langerhans cell histiocytosis.

Abstract

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