False-positive PET/CT for lymphoma recurrence secondary to Langerhans cell histiocytosis.

Joseph S. Fotos, Donald J. Flemming, Mark Tulchinsky

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


A 28-year-old man with a history of Hodgkin lymphoma that was intensely [F-18]fluoro-2-deoxy-D-glucose-avid at diagnosis had achieved complete remission following appropriate therapy. On surveillance positron emission tomography/computed tomography (CT), new, intensely [F-18]fluoro-2-deoxy-D-glucose-avid lesions (lytic on CT) were seen within the vertebral body of C7, left scapula, and right glenoid. The findings of a biopsy revealed these lesions to be Langerhans cell histiocytosis. Langerhans cell histiocytosis arising in the context of lymphoma is a well-documented phenomenon, and its appearance on positron emission tomography/CT cannot be conclusively distinguished from lymphoma recurrence. This manuscript emphasizes the necessity of biopsy to ensure correct diagnosis and subsequent correct therapy.

Original languageEnglish (US)
Pages (from-to)717-719
Number of pages3
JournalClinical nuclear medicine
Issue number8
StatePublished - Aug 2011

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging


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