FANCD2 Hurdles the DNA Interstrand Crosslink

George Lucian Moldovan; Alan D. D'Andrea

doi:10.1016/j.cell.2009.12.006

FANCD2 Hurdles the DNA Interstrand Crosslink

George Lucian Moldovan
, Alan D. D'Andrea

Research output: Contribution to journal › Short survey › peer-review

19 Scopus citations

Abstract

Left unrepaired, DNA interstrand crosslinks represent impassable hurdles for DNA replication, and their removal is a complicated stepwise process involving a variety of enzymes. In a recent paper in Science, Knipscheer et al. (2009) demonstrate that the Fanconi Anemia protein FANCD2 promotes multiple steps of the crosslink repair process.

Original language	English (US)
Pages (from-to)	1222-1224
Number of pages	3
Journal	Cell
Volume	139
Issue number	7
DOIs	https://doi.org/10.1016/j.cell.2009.12.006
State	Published - Dec 24 2009

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2009.12.006

Cite this

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title = "FANCD2 Hurdles the DNA Interstrand Crosslink",

abstract = "Left unrepaired, DNA interstrand crosslinks represent impassable hurdles for DNA replication, and their removal is a complicated stepwise process involving a variety of enzymes. In a recent paper in Science, Knipscheer et al. (2009) demonstrate that the Fanconi Anemia protein FANCD2 promotes multiple steps of the crosslink repair process.",

author = "Moldovan, \{George Lucian\} and D'Andrea, \{Alan D.\}",

note = "Funding Information: G.-L.M. is supported by a Human Frontiers Science Program Organization postdoctoral fellowship. The authors are also supported by NIH grant PO1CA092584.",

year = "2009",

month = dec,

day = "24",

doi = "10.1016/j.cell.2009.12.006",

language = "English (US)",

volume = "139",

pages = "1222--1224",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

number = "7",

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TY - JOUR

T1 - FANCD2 Hurdles the DNA Interstrand Crosslink

AU - Moldovan, George Lucian

AU - D'Andrea, Alan D.

N1 - Funding Information: G.-L.M. is supported by a Human Frontiers Science Program Organization postdoctoral fellowship. The authors are also supported by NIH grant PO1CA092584.

PY - 2009/12/24

Y1 - 2009/12/24

N2 - Left unrepaired, DNA interstrand crosslinks represent impassable hurdles for DNA replication, and their removal is a complicated stepwise process involving a variety of enzymes. In a recent paper in Science, Knipscheer et al. (2009) demonstrate that the Fanconi Anemia protein FANCD2 promotes multiple steps of the crosslink repair process.

AB - Left unrepaired, DNA interstrand crosslinks represent impassable hurdles for DNA replication, and their removal is a complicated stepwise process involving a variety of enzymes. In a recent paper in Science, Knipscheer et al. (2009) demonstrate that the Fanconi Anemia protein FANCD2 promotes multiple steps of the crosslink repair process.

UR - https://www.scopus.com/pages/publications/72249101547

UR - https://www.scopus.com/pages/publications/72249101547#tab=citedBy

U2 - 10.1016/j.cell.2009.12.006

DO - 10.1016/j.cell.2009.12.006

M3 - Short survey

C2 - 20064367

AN - SCOPUS:72249101547

SN - 0092-8674

VL - 139

SP - 1222

EP - 1224

JO - Cell

JF - Cell

IS - 7

ER -

FANCD2 Hurdles the DNA Interstrand Crosslink

Abstract

All Science Journal Classification (ASJC) codes

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