TY - JOUR
T1 - Fast screening of protein surfaces using geometric invariant fingerprints
AU - Yin, Shuangye
AU - Proctor, Elizabeth A.
AU - Lugovskoy, Alexey A.
AU - Dokholyan, Nikolay V.
PY - 2009/9/29
Y1 - 2009/9/29
N2 - We develop a rapid and efficient method for the comparison of protein local surface similarities using geometric invariants (fingerprints). By combining fast fingerprint comparison with explicit alignment, we successfully screen the entire Protein Data Bank for proteins that possess local surface similarities. Our method is independent of sequence and fold similarities, and has potential application to protein structure annotation and protein-protein interface design.
AB - We develop a rapid and efficient method for the comparison of protein local surface similarities using geometric invariants (fingerprints). By combining fast fingerprint comparison with explicit alignment, we successfully screen the entire Protein Data Bank for proteins that possess local surface similarities. Our method is independent of sequence and fold similarities, and has potential application to protein structure annotation and protein-protein interface design.
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U2 - 10.1073/pnas.0906146106
DO - 10.1073/pnas.0906146106
M3 - Article
C2 - 19805347
AN - SCOPUS:70349730037
SN - 0027-8424
VL - 106
SP - 16622
EP - 16626
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 39
ER -