TY - JOUR
T1 - Fatal heart disease among cancer patients
AU - Stoltzfus, Kelsey C.
AU - Zhang, Ying
AU - Sturgeon, Kathleen
AU - Sinoway, Lawrence I.
AU - Trifiletti, Daniel M.
AU - Chinchilli, Vernon M.
AU - Zaorsky, Nicholas G.
N1 - Funding Information:
D.M.T reports clinical trial research support from Novocure, and publishing fees from Springer Inc. for projects outside the submitted work. K.S. reports funding from the National Center for Advancing Translational Sciences (NCATS) at the National Institute of Health [grant numbers 5 UL1 TR002014, 5 KL2 TR002015] for projects outside the submitted work. Novocure, Springer Inc., and the National Center for Advancing Translational Sciences had no role in the design of this study nor the execution, analyses, interpretation of the data, or decision to submit results. N.G.Z. is supported by the National Institutes of Health LRP 1 L30 CA231572-01 and the American Cancer Society, CSDG-CCE 133738. N.G.Z. received personal fees from Springer Nature, Inc for his textbook Absolute Clinical Radiation Oncology Review. He has also received payments from Weatherby Healthcare. Other authors declare no competing risks.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - As the overlap between heart disease and cancer patients increases as cancer-specific mortality is decreasing and the surviving population is aging, it is necessary to identify cancer patients who are at an increased risk of death from heart disease. The purpose of this study is to identify cancer patients at highest risk of fatal heart disease compared to the general population and other cancer patients at risk of death during the study time period. Here we report that 394,849 of the 7,529,481 cancer patients studied died of heart disease. The heart disease-specific mortality rate is 10.61/10,000-person years, and the standardized mortality ratio (SMR) of fatal heart disease is 2.24 (95% CI: 2.23–2.25). Compared to other cancer patients, patients who are older, male, African American, and unmarried are at a greatest risk of fatal heart disease. For almost all cancer survivors, the risk of fatal heart disease increases with time.
AB - As the overlap between heart disease and cancer patients increases as cancer-specific mortality is decreasing and the surviving population is aging, it is necessary to identify cancer patients who are at an increased risk of death from heart disease. The purpose of this study is to identify cancer patients at highest risk of fatal heart disease compared to the general population and other cancer patients at risk of death during the study time period. Here we report that 394,849 of the 7,529,481 cancer patients studied died of heart disease. The heart disease-specific mortality rate is 10.61/10,000-person years, and the standardized mortality ratio (SMR) of fatal heart disease is 2.24 (95% CI: 2.23–2.25). Compared to other cancer patients, patients who are older, male, African American, and unmarried are at a greatest risk of fatal heart disease. For almost all cancer survivors, the risk of fatal heart disease increases with time.
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U2 - 10.1038/s41467-020-15639-5
DO - 10.1038/s41467-020-15639-5
M3 - Article
C2 - 32332714
AN - SCOPUS:85083834925
SN - 2041-1723
VL - 11
JO - Nature communications
JF - Nature communications
IS - 1
M1 - 2011
ER -