Feasibility of dexmedetomidine as sole analgesic agent during robotic urological surgery: A pilot study

Bright Jebaraj, Rashmi Ramachandran, Vimi Rewari, Anjan Trikha, Chandralekha, Rajeev Kumar, Prem N. Dogra

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Background and Aims: Opioid-free anesthesia decreases postoperative nausea and vomiting, emergence agitation, prolonged sedation, ileus, and urinary retention. The feasibility of the use of dexmedetomidine as sole analgesic agent has been shown in patients undergoing bariatric and gynecological laparoscopic surgery. We explored its use for robotic urological surgery. Material and Methods: Thirty patients were randomized to receive either dexmedetomidine (Group D) or fentanyl (Group F) along with total intravenous anesthesia with propofol. The hemodynamic parameters and number of doses of rescue analgesics used intraoperatively and postoperatively were noted. Recovery parameters at the end of surgery were also recorded. Results: The dose of intraoperative rescue fentanyl was not significantly different between groups (P = 0.13). The hemodynamic profile of patients in the two groups was comparable except the heart rate was significantly more in Group D after intubation and at 60 min. The mean arterial pressure was significantly lower after the initial loading dose of study drug in Group D. The recovery profiles were not significantly different between groups. Conclusion: The study reveals that dexmedetomidine has equal analgesic efficacy as fentanyl for intraoperative use and can be used as the sole analgesic agent in patients undergoing robotic urological surgery.

Original languageEnglish (US)
Pages (from-to)187-192
Number of pages6
JournalJournal of Anaesthesiology Clinical Pharmacology
Issue number2
StatePublished - Apr 1 2017

All Science Journal Classification (ASJC) codes

  • General Pharmacology, Toxicology and Pharmaceutics
  • Pharmacology (medical)
  • Anesthesiology and Pain Medicine

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