Feasibility of probing boundary morphology of structured materials by 2D NMR q-space imaging

Chih Liang Chin, Felix W. Wehrli, Scott N. Hwang, Dwight L. Jaggard, David B. Hackney, Suzanne W. Wehrli

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


It is well known that one-dimensional (1D) q-space imaging allows retrieval of structural information at cellular resolution. Here we demonstrate by simulation that boundary morphology of structured materials can be derived from 2D q-space mapping. Based on a finite-difference model for restricted diffusion, 2D q-space maps obtained from water diffusion inside apertures at various levels of asperity were simulated. The results indicate that the observed ring patterns (diffraction minima) reveal the boundary profiles of the apertures but become blurred in the case of significant variation in aperture size. For uniform size distribution of apertures, a quantitative measure of surface roughness can be established by means of spatial autocorrelation analysis. The results suggest that 2D q-space imaging may allow probing of the boundary morphology of structured materials and possibly biological cells.

Original languageEnglish (US)
Pages (from-to)20-25
Number of pages6
JournalJournal of Magnetic Resonance
Issue number1
StatePublished - Jan 2003

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Nuclear and High Energy Physics
  • Condensed Matter Physics


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