Feature-based design of bio-degradable micro-patterned structures

Ibrahim T. Ozbolat; Michelle Marchany; Joseph A. Gardella; Frank V. Bright; Alex N. Cartwright; Robert Hard; Wesley L. Hicks; Bahattin Koc

doi:10.3722/cadaps.2009.661-671

Feature-based design of bio-degradable micro-patterned structures

Ibrahim T. Ozbolat, Michelle Marchany, Joseph A. Gardella, Frank V. Bright, Alex N. Cartwright, Robert Hard, Wesley L. Hicks, Bahattin Koc

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

This paper presents a novelfeature-based variational modeling to control the bio-degradation process and thus material release kinetics of biodegradable micro-structures. Pattern architecture of micro-structure is varied according to the predetermined degradation profile over the micro-structure based on tissue engineering requirements. Optimum pattern architecture is generated over the micro-structure with varying geometric features and degradation kinetics.Several micro-pattern examples are provided with different patterning features (PFs) and degradation profiles, and their time baseddegradation profilesarecalculated based on the developed biodegradation model. An experimental study of degradation process is also developed to compare a fabricated micro-structured biodegradable material to the developed computational model.

Original language	English (US)
Pages (from-to)	661-671
Number of pages	11
Journal	Computer-Aided Design and Applications
Volume	6
Issue number	5
DOIs	https://doi.org/10.3722/cadaps.2009.661-671
State	Published - 2009

All Science Journal Classification (ASJC) codes

Computational Mechanics
Computer Graphics and Computer-Aided Design
Computational Mathematics

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abstract = "This paper presents a novelfeature-based variational modeling to control the bio-degradation process and thus material release kinetics of biodegradable micro-structures. Pattern architecture of micro-structure is varied according to the predetermined degradation profile over the micro-structure based on tissue engineering requirements. Optimum pattern architecture is generated over the micro-structure with varying geometric features and degradation kinetics.Several micro-pattern examples are provided with different patterning features (PFs) and degradation profiles, and their time baseddegradation profilesarecalculated based on the developed biodegradation model. An experimental study of degradation process is also developed to compare a fabricated micro-structured biodegradable material to the developed computational model.",

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AU - Ozbolat, Ibrahim T.

AU - Marchany, Michelle

AU - Gardella, Joseph A.

AU - Bright, Frank V.

AU - Cartwright, Alex N.

AU - Hard, Robert

AU - Hicks, Wesley L.

AU - Koc, Bahattin

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AB - This paper presents a novelfeature-based variational modeling to control the bio-degradation process and thus material release kinetics of biodegradable micro-structures. Pattern architecture of micro-structure is varied according to the predetermined degradation profile over the micro-structure based on tissue engineering requirements. Optimum pattern architecture is generated over the micro-structure with varying geometric features and degradation kinetics.Several micro-pattern examples are provided with different patterning features (PFs) and degradation profiles, and their time baseddegradation profilesarecalculated based on the developed biodegradation model. An experimental study of degradation process is also developed to compare a fabricated micro-structured biodegradable material to the developed computational model.

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Feature-based design of bio-degradable micro-patterned structures

Abstract

All Science Journal Classification (ASJC) codes

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