Febrile neutropenia with thrombocytopenia after infliximab induction in a patient with ulcerative colitis

Gustavo Gomez; Shifa Umar; Mohammad Bilal; Cristina Strahotin; Kofi Clarke

doi:10.1159/000448071

Febrile neutropenia with thrombocytopenia after infliximab induction in a patient with ulcerative colitis

Gustavo Gomez, Shifa Umar, Mohammad Bilal, Cristina Strahotin, Kofi Clarke

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2 Scopus citations

Abstract

A 34-year-old female with left-sided ulcerative colitis (UC) developed severe febrile neutropenia/thrombocytopenia soon after infliximab induction therapy. There was no other plausible cause of the cell line abnormalities other than an accurate temporal association with infliximab administration. Supportive care, broad-spectrum antibiotic, and single dose of filgrastim was given on day 5 of admission due to persistently low absolute neutrophil count and fevers. The cell lines recovered, fever resolved and the patient made a complete clinical recovery. Clinicians should be aware of this potential life-threatening inflixmab side effect previously unreported in adults with UC.

Original language	English (US)
Pages (from-to)	596-599
Number of pages	4
Journal	Case Reports in Gastroenterology
Volume	10
Issue number	3
DOIs	https://doi.org/10.1159/000448071
State	Published - Oct 6 2016

All Science Journal Classification (ASJC) codes

Gastroenterology

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10.1159/000448071

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title = "Febrile neutropenia with thrombocytopenia after infliximab induction in a patient with ulcerative colitis",

abstract = "A 34-year-old female with left-sided ulcerative colitis (UC) developed severe febrile neutropenia/thrombocytopenia soon after infliximab induction therapy. There was no other plausible cause of the cell line abnormalities other than an accurate temporal association with infliximab administration. Supportive care, broad-spectrum antibiotic, and single dose of filgrastim was given on day 5 of admission due to persistently low absolute neutrophil count and fevers. The cell lines recovered, fever resolved and the patient made a complete clinical recovery. Clinicians should be aware of this potential life-threatening inflixmab side effect previously unreported in adults with UC.",

author = "Gustavo Gomez and Shifa Umar and Mohammad Bilal and Cristina Strahotin and Kofi Clarke",

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T1 - Febrile neutropenia with thrombocytopenia after infliximab induction in a patient with ulcerative colitis

AU - Gomez, Gustavo

AU - Umar, Shifa

AU - Bilal, Mohammad

AU - Strahotin, Cristina

AU - Clarke, Kofi

PY - 2016/10/6

Y1 - 2016/10/6

N2 - A 34-year-old female with left-sided ulcerative colitis (UC) developed severe febrile neutropenia/thrombocytopenia soon after infliximab induction therapy. There was no other plausible cause of the cell line abnormalities other than an accurate temporal association with infliximab administration. Supportive care, broad-spectrum antibiotic, and single dose of filgrastim was given on day 5 of admission due to persistently low absolute neutrophil count and fevers. The cell lines recovered, fever resolved and the patient made a complete clinical recovery. Clinicians should be aware of this potential life-threatening inflixmab side effect previously unreported in adults with UC.

AB - A 34-year-old female with left-sided ulcerative colitis (UC) developed severe febrile neutropenia/thrombocytopenia soon after infliximab induction therapy. There was no other plausible cause of the cell line abnormalities other than an accurate temporal association with infliximab administration. Supportive care, broad-spectrum antibiotic, and single dose of filgrastim was given on day 5 of admission due to persistently low absolute neutrophil count and fevers. The cell lines recovered, fever resolved and the patient made a complete clinical recovery. Clinicians should be aware of this potential life-threatening inflixmab side effect previously unreported in adults with UC.

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Febrile neutropenia with thrombocytopenia after infliximab induction in a patient with ulcerative colitis

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