FeLV-FAIDS-induced immunodeficiency syndrome in cats

James I. Mullins; Edward A. Hoover; Julie Overbaugh; Sandra L. Quackenbush; Peter R. Donahue; Mary L. Poss

doi:10.1016/0165-2427(89)90127-X

FeLV-FAIDS-induced immunodeficiency syndrome in cats

James I. Mullins, Edward A. Hoover, Julie Overbaugh, Sandra L. Quackenbush, Peter R. Donahue, Mary L. Poss

Biology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Findings are reviewed, relevant to elucidation of the pathogenic, genetic and biochemical properties of a single, genetically heterogeneous isolate of feline leukemia virus (FeLV-FAIDS) shown to induce fatal immunodeficiency disease in nearly 100% of inoculated cats. Hypotheses are suggested which pertain to the mechanism of T-cell killing by this virus, and which extrapolate findings in the FeLV-FAIDS animal model to AIDS induced in humans by human immunodeficiency virus (HIV).

Original language	English (US)
Pages (from-to)	25-37
Number of pages	13
Journal	Veterinary Immunology and Immunopathology
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/0165-2427(89)90127-X
State	Published - May 1989

All Science Journal Classification (ASJC) codes

Immunology
General Veterinary

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10.1016/0165-2427(89)90127-X

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title = "FeLV-FAIDS-induced immunodeficiency syndrome in cats",

abstract = "Findings are reviewed, relevant to elucidation of the pathogenic, genetic and biochemical properties of a single, genetically heterogeneous isolate of feline leukemia virus (FeLV-FAIDS) shown to induce fatal immunodeficiency disease in nearly 100% of inoculated cats. Hypotheses are suggested which pertain to the mechanism of T-cell killing by this virus, and which extrapolate findings in the FeLV-FAIDS animal model to AIDS induced in humans by human immunodeficiency virus (HIV).",

author = "Mullins, {James I.} and Hoover, {Edward A.} and Julie Overbaugh and Quackenbush, {Sandra L.} and Donahue, {Peter R.} and Poss, {Mary L.}",

note = "Funding Information: This work was supported by grants CA43216, CA01058 and AI25273 from the National Institutes of Health, and by a grant from the American Foundation for AIDS Research.",

year = "1989",

month = may,

doi = "10.1016/0165-2427(89)90127-X",

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T1 - FeLV-FAIDS-induced immunodeficiency syndrome in cats

AU - Mullins, James I.

AU - Hoover, Edward A.

AU - Overbaugh, Julie

AU - Quackenbush, Sandra L.

AU - Donahue, Peter R.

AU - Poss, Mary L.

N1 - Funding Information: This work was supported by grants CA43216, CA01058 and AI25273 from the National Institutes of Health, and by a grant from the American Foundation for AIDS Research.

PY - 1989/5

Y1 - 1989/5

N2 - Findings are reviewed, relevant to elucidation of the pathogenic, genetic and biochemical properties of a single, genetically heterogeneous isolate of feline leukemia virus (FeLV-FAIDS) shown to induce fatal immunodeficiency disease in nearly 100% of inoculated cats. Hypotheses are suggested which pertain to the mechanism of T-cell killing by this virus, and which extrapolate findings in the FeLV-FAIDS animal model to AIDS induced in humans by human immunodeficiency virus (HIV).

AB - Findings are reviewed, relevant to elucidation of the pathogenic, genetic and biochemical properties of a single, genetically heterogeneous isolate of feline leukemia virus (FeLV-FAIDS) shown to induce fatal immunodeficiency disease in nearly 100% of inoculated cats. Hypotheses are suggested which pertain to the mechanism of T-cell killing by this virus, and which extrapolate findings in the FeLV-FAIDS animal model to AIDS induced in humans by human immunodeficiency virus (HIV).

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AN - SCOPUS:0024400331

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VL - 21

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EP - 37

JO - Veterinary Immunology and Immunopathology

JF - Veterinary Immunology and Immunopathology

IS - 1

ER -

FeLV-FAIDS-induced immunodeficiency syndrome in cats

Abstract

All Science Journal Classification (ASJC) codes

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