TY - JOUR
T1 - FeLV-FAIDS-induced immunodeficiency syndrome in cats
AU - Mullins, James I.
AU - Hoover, Edward A.
AU - Overbaugh, Julie
AU - Quackenbush, Sandra L.
AU - Donahue, Peter R.
AU - Poss, Mary L.
N1 - Funding Information:
This work was supported by grants CA43216, CA01058 and AI25273 from the National Institutes of Health, and by a grant from the American Foundation for AIDS Research.
PY - 1989/5
Y1 - 1989/5
N2 - Findings are reviewed, relevant to elucidation of the pathogenic, genetic and biochemical properties of a single, genetically heterogeneous isolate of feline leukemia virus (FeLV-FAIDS) shown to induce fatal immunodeficiency disease in nearly 100% of inoculated cats. Hypotheses are suggested which pertain to the mechanism of T-cell killing by this virus, and which extrapolate findings in the FeLV-FAIDS animal model to AIDS induced in humans by human immunodeficiency virus (HIV).
AB - Findings are reviewed, relevant to elucidation of the pathogenic, genetic and biochemical properties of a single, genetically heterogeneous isolate of feline leukemia virus (FeLV-FAIDS) shown to induce fatal immunodeficiency disease in nearly 100% of inoculated cats. Hypotheses are suggested which pertain to the mechanism of T-cell killing by this virus, and which extrapolate findings in the FeLV-FAIDS animal model to AIDS induced in humans by human immunodeficiency virus (HIV).
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U2 - 10.1016/0165-2427(89)90127-X
DO - 10.1016/0165-2427(89)90127-X
M3 - Article
C2 - 2549691
AN - SCOPUS:0024400331
SN - 0165-2427
VL - 21
SP - 25
EP - 37
JO - Veterinary Immunology and Immunopathology
JF - Veterinary Immunology and Immunopathology
IS - 1
ER -
