FeLV-FAIDS-induced immunodeficiency syndrome in cats

James I. Mullins; Edward A. Hoover; Julie Overbaugh; Sandra L. Quackenbush; Peter R. Donahue; Mary L. Poss

doi:10.1016/0165-2427(89)90127-X

FeLV-FAIDS-induced immunodeficiency syndrome in cats

James I. Mullins
, Edward A. Hoover
, Julie Overbaugh
, Sandra L. Quackenbush
, Peter R. Donahue
, Mary L. Poss

Biology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Findings are reviewed, relevant to elucidation of the pathogenic, genetic and biochemical properties of a single, genetically heterogeneous isolate of feline leukemia virus (FeLV-FAIDS) shown to induce fatal immunodeficiency disease in nearly 100% of inoculated cats. Hypotheses are suggested which pertain to the mechanism of T-cell killing by this virus, and which extrapolate findings in the FeLV-FAIDS animal model to AIDS induced in humans by human immunodeficiency virus (HIV).

Original language	English (US)
Pages (from-to)	25-37
Number of pages	13
Journal	Veterinary Immunology and Immunopathology
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/0165-2427(89)90127-X
State	Published - May 1989

All Science Journal Classification (ASJC) codes

Immunology
General Veterinary

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0165-2427(89)90127-X

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title = "FeLV-FAIDS-induced immunodeficiency syndrome in cats",

abstract = "Findings are reviewed, relevant to elucidation of the pathogenic, genetic and biochemical properties of a single, genetically heterogeneous isolate of feline leukemia virus (FeLV-FAIDS) shown to induce fatal immunodeficiency disease in nearly 100\% of inoculated cats. Hypotheses are suggested which pertain to the mechanism of T-cell killing by this virus, and which extrapolate findings in the FeLV-FAIDS animal model to AIDS induced in humans by human immunodeficiency virus (HIV).",

author = "Mullins, \{James I.\} and Hoover, \{Edward A.\} and Julie Overbaugh and Quackenbush, \{Sandra L.\} and Donahue, \{Peter R.\} and Poss, \{Mary L.\}",

note = "Funding Information: This work was supported by grants CA43216, CA01058 and AI25273 from the National Institutes of Health, and by a grant from the American Foundation for AIDS Research.",

year = "1989",

month = may,

doi = "10.1016/0165-2427(89)90127-X",

language = "English (US)",

volume = "21",

pages = "25--37",

journal = "Veterinary Immunology and Immunopathology",

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}

TY - JOUR

T1 - FeLV-FAIDS-induced immunodeficiency syndrome in cats

AU - Mullins, James I.

AU - Hoover, Edward A.

AU - Overbaugh, Julie

AU - Quackenbush, Sandra L.

AU - Donahue, Peter R.

AU - Poss, Mary L.

N1 - Funding Information: This work was supported by grants CA43216, CA01058 and AI25273 from the National Institutes of Health, and by a grant from the American Foundation for AIDS Research.

PY - 1989/5

Y1 - 1989/5

N2 - Findings are reviewed, relevant to elucidation of the pathogenic, genetic and biochemical properties of a single, genetically heterogeneous isolate of feline leukemia virus (FeLV-FAIDS) shown to induce fatal immunodeficiency disease in nearly 100% of inoculated cats. Hypotheses are suggested which pertain to the mechanism of T-cell killing by this virus, and which extrapolate findings in the FeLV-FAIDS animal model to AIDS induced in humans by human immunodeficiency virus (HIV).

AB - Findings are reviewed, relevant to elucidation of the pathogenic, genetic and biochemical properties of a single, genetically heterogeneous isolate of feline leukemia virus (FeLV-FAIDS) shown to induce fatal immunodeficiency disease in nearly 100% of inoculated cats. Hypotheses are suggested which pertain to the mechanism of T-cell killing by this virus, and which extrapolate findings in the FeLV-FAIDS animal model to AIDS induced in humans by human immunodeficiency virus (HIV).

UR - https://www.scopus.com/pages/publications/0024400331

UR - https://www.scopus.com/pages/publications/0024400331#tab=citedBy

U2 - 10.1016/0165-2427(89)90127-X

DO - 10.1016/0165-2427(89)90127-X

M3 - Article

C2 - 2549691

AN - SCOPUS:0024400331

SN - 0165-2427

VL - 21

SP - 25

EP - 37

JO - Veterinary Immunology and Immunopathology

JF - Veterinary Immunology and Immunopathology

IS - 1

ER -

FeLV-FAIDS-induced immunodeficiency syndrome in cats

Abstract

All Science Journal Classification (ASJC) codes

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