TY - JOUR
T1 - Ferrying Wingless across the Synaptic Cleft
AU - Zarnescu, Daniela C.
AU - Zinsmaier, Konrad E.
N1 - Funding Information:
We thank Jinhui Zhang for help preparing the figure. K.E.Z. is supported by funds from NINDS (R01NS052664) and D.C.Z. from DOD (W81XWH-09-1-0273), AHA (SDG 0930170N), and ABRC (0820).
PY - 2009/10/16
Y1 - 2009/10/16
N2 - Secreted Wnt morphogens mediate cell-cell communication, but the mechanism of Wnt transfer between cells is unknown. Korkut et al. (2009) report that the transmembrane protein Evi is a versatile carrier that guides Wingless to presynaptic terminals of motor neurons and then escorts it across the synaptic cleft. In postsynaptic muscles, Evi promotes Frizzled-2 trafficking.
AB - Secreted Wnt morphogens mediate cell-cell communication, but the mechanism of Wnt transfer between cells is unknown. Korkut et al. (2009) report that the transmembrane protein Evi is a versatile carrier that guides Wingless to presynaptic terminals of motor neurons and then escorts it across the synaptic cleft. In postsynaptic muscles, Evi promotes Frizzled-2 trafficking.
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U2 - 10.1016/j.cell.2009.09.032
DO - 10.1016/j.cell.2009.09.032
M3 - Short survey
C2 - 19837027
AN - SCOPUS:70349845437
SN - 0092-8674
VL - 139
SP - 229
EP - 231
JO - Cell
JF - Cell
IS - 2
ER -