Ferrying Wingless across the Synaptic Cleft

Daniela C. Zarnescu; Konrad E. Zinsmaier

doi:10.1016/j.cell.2009.09.032

Ferrying Wingless across the Synaptic Cleft

Daniela C. Zarnescu
, Konrad E. Zinsmaier

Research output: Contribution to journal › Short survey › peer-review

3 Scopus citations

Abstract

Secreted Wnt morphogens mediate cell-cell communication, but the mechanism of Wnt transfer between cells is unknown. Korkut et al. (2009) report that the transmembrane protein Evi is a versatile carrier that guides Wingless to presynaptic terminals of motor neurons and then escorts it across the synaptic cleft. In postsynaptic muscles, Evi promotes Frizzled-2 trafficking.

Original language	English (US)
Pages (from-to)	229-231
Number of pages	3
Journal	Cell
Volume	139
Issue number	2
DOIs	https://doi.org/10.1016/j.cell.2009.09.032
State	Published - Oct 16 2009

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2009.09.032

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@article{b44f5ad7fcb348e0b3d16104a1deb25d,

title = "Ferrying Wingless across the Synaptic Cleft",

abstract = "Secreted Wnt morphogens mediate cell-cell communication, but the mechanism of Wnt transfer between cells is unknown. Korkut et al. (2009) report that the transmembrane protein Evi is a versatile carrier that guides Wingless to presynaptic terminals of motor neurons and then escorts it across the synaptic cleft. In postsynaptic muscles, Evi promotes Frizzled-2 trafficking.",

author = "Zarnescu, \{Daniela C.\} and Zinsmaier, \{Konrad E.\}",

note = "Funding Information: We thank Jinhui Zhang for help preparing the figure. K.E.Z. is supported by funds from NINDS (R01NS052664) and D.C.Z. from DOD (W81XWH-09-1-0273), AHA (SDG 0930170N), and ABRC (0820).",

year = "2009",

month = oct,

day = "16",

doi = "10.1016/j.cell.2009.09.032",

language = "English (US)",

volume = "139",

pages = "229--231",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Ferrying Wingless across the Synaptic Cleft

AU - Zarnescu, Daniela C.

AU - Zinsmaier, Konrad E.

N1 - Funding Information: We thank Jinhui Zhang for help preparing the figure. K.E.Z. is supported by funds from NINDS (R01NS052664) and D.C.Z. from DOD (W81XWH-09-1-0273), AHA (SDG 0930170N), and ABRC (0820).

PY - 2009/10/16

Y1 - 2009/10/16

N2 - Secreted Wnt morphogens mediate cell-cell communication, but the mechanism of Wnt transfer between cells is unknown. Korkut et al. (2009) report that the transmembrane protein Evi is a versatile carrier that guides Wingless to presynaptic terminals of motor neurons and then escorts it across the synaptic cleft. In postsynaptic muscles, Evi promotes Frizzled-2 trafficking.

AB - Secreted Wnt morphogens mediate cell-cell communication, but the mechanism of Wnt transfer between cells is unknown. Korkut et al. (2009) report that the transmembrane protein Evi is a versatile carrier that guides Wingless to presynaptic terminals of motor neurons and then escorts it across the synaptic cleft. In postsynaptic muscles, Evi promotes Frizzled-2 trafficking.

UR - https://www.scopus.com/pages/publications/70349845437

UR - https://www.scopus.com/pages/publications/70349845437#tab=citedBy

U2 - 10.1016/j.cell.2009.09.032

DO - 10.1016/j.cell.2009.09.032

M3 - Short survey

C2 - 19837027

AN - SCOPUS:70349845437

SN - 0092-8674

VL - 139

SP - 229

EP - 231

JO - Cell

JF - Cell

IS - 2

ER -

Ferrying Wingless across the Synaptic Cleft

Abstract

All Science Journal Classification (ASJC) codes

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