Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p

C. I. Amos; D. Bali; T. J. Thiel; J. P. Anderson; I. Gourley; M. L. Frazier; P. M. Lynch; M. A. Luchtefeld; A. Young; T. J. McGarrity; M. F. Seldin

Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p

C. I. Amos
, D. Bali
, T. J. Thiel
, J. P. Anderson
, I. Gourley
, M. L. Frazier
, P. M. Lynch
, M. A. Luchtefeld
, A. Young
, T. J. McGarrity
, M. F. Seldin

Research output: Contribution to journal › Article › peer-review

Abstract

Peutz-Jeghers syndrome (PJS) was recently mapped in a single report to the telomeric region of chromosome 19p (A. Hemminki et al., Nat. Genet., 15: 87-90, 1997). Our studies confirm this location and provide further localization of the PJS locus. In the five families examined, there were no recombinants with the marker D19S886. The multipoint log odds score at D19S886 is 7.52, and we found no evidence for genetic heterogeneity. We also found that all carriers expressed the PJS phenotype and no noncarriers displayed PJS sequellae, indicating complete penetrance with no sporadic cases.

Original language	English (US)
Pages (from-to)	3653-3656
Number of pages	4
Journal	Cancer Research
Volume	57
Issue number	17
State	Published - 1997

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

Cite this

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title = "Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p",

abstract = "Peutz-Jeghers syndrome (PJS) was recently mapped in a single report to the telomeric region of chromosome 19p (A. Hemminki et al., Nat. Genet., 15: 87-90, 1997). Our studies confirm this location and provide further localization of the PJS locus. In the five families examined, there were no recombinants with the marker D19S886. The multipoint log odds score at D19S886 is 7.52, and we found no evidence for genetic heterogeneity. We also found that all carriers expressed the PJS phenotype and no noncarriers displayed PJS sequellae, indicating complete penetrance with no sporadic cases.",

author = "Amos, \{C. I.\} and D. Bali and Thiel, \{T. J.\} and Anderson, \{J. P.\} and I. Gourley and Frazier, \{M. L.\} and Lynch, \{P. M.\} and Luchtefeld, \{M. A.\} and A. Young and McGarrity, \{T. J.\} and Seldin, \{M. F.\}",

year = "1997",

language = "English (US)",

volume = "57",

pages = "3653--3656",

journal = "Cancer Research",

issn = "0008-5472",

publisher = "American Association for Cancer Research Inc.",

number = "17",

}

TY - JOUR

T1 - Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p

AU - Amos, C. I.

AU - Bali, D.

AU - Thiel, T. J.

AU - Anderson, J. P.

AU - Gourley, I.

AU - Frazier, M. L.

AU - Lynch, P. M.

AU - Luchtefeld, M. A.

AU - Young, A.

AU - McGarrity, T. J.

AU - Seldin, M. F.

PY - 1997

Y1 - 1997

N2 - Peutz-Jeghers syndrome (PJS) was recently mapped in a single report to the telomeric region of chromosome 19p (A. Hemminki et al., Nat. Genet., 15: 87-90, 1997). Our studies confirm this location and provide further localization of the PJS locus. In the five families examined, there were no recombinants with the marker D19S886. The multipoint log odds score at D19S886 is 7.52, and we found no evidence for genetic heterogeneity. We also found that all carriers expressed the PJS phenotype and no noncarriers displayed PJS sequellae, indicating complete penetrance with no sporadic cases.

AB - Peutz-Jeghers syndrome (PJS) was recently mapped in a single report to the telomeric region of chromosome 19p (A. Hemminki et al., Nat. Genet., 15: 87-90, 1997). Our studies confirm this location and provide further localization of the PJS locus. In the five families examined, there were no recombinants with the marker D19S886. The multipoint log odds score at D19S886 is 7.52, and we found no evidence for genetic heterogeneity. We also found that all carriers expressed the PJS phenotype and no noncarriers displayed PJS sequellae, indicating complete penetrance with no sporadic cases.

UR - https://www.scopus.com/pages/publications/0030820394

UR - https://www.scopus.com/pages/publications/0030820394#tab=citedBy

M3 - Article

C2 - 9288765

AN - SCOPUS:0030820394

SN - 0008-5472

VL - 57

SP - 3653

EP - 3656

JO - Cancer Research

JF - Cancer Research

IS - 17

ER -

Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p

Abstract

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All Science Journal Classification (ASJC) codes

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