Fix L, a haemoglobin that acts as an oxygen sensor: Signalling mechanism and structural basis of its homology with PAS domains

Max F. Perutz; Massimo Paoli; Arthur M. Lesk

doi:10.1016/S1074-5521(99)80121-5

Fix L, a haemoglobin that acts as an oxygen sensor: Signalling mechanism and structural basis of its homology with PAS domains

Max F. Perutz, Massimo Paoli, Arthur M. Lesk

Biochemistry & Molecular Biology

Research output: Contribution to journal › Short survey › peer-review

57 Scopus citations

Abstract

Fix L, which contains a haemoglobin domain homologous to the PAS family and a histidine kinase complex that regulates expression of nitrogenase trigger stereochemical changes in and around the haem that, together with steric effects, control the activity of the kinase. Homology with the PAS family is based on a common core of about 20 structurally equivalent sites from which polar residues are excluded.

Original language	English (US)
Pages (from-to)	R291-R297
Journal	Chemistry and Biology
Volume	6
Issue number	11
DOIs	https://doi.org/10.1016/S1074-5521(99)80121-5
State	Published - Nov 1999

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmacology
Drug Discovery
Clinical Biochemistry

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10.1016/S1074-5521(99)80121-5

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abstract = "Fix L, which contains a haemoglobin domain homologous to the PAS family and a histidine kinase complex that regulates expression of nitrogenase trigger stereochemical changes in and around the haem that, together with steric effects, control the activity of the kinase. Homology with the PAS family is based on a common core of about 20 structurally equivalent sites from which polar residues are excluded.",

author = "Perutz, {Max F.} and Massimo Paoli and Lesk, {Arthur M.}",

note = "Funding Information: M.F.P. and A.M.L. thank the Wellcome Trust and M.P. thanks the Biological and Biotechnological Research Council for support.",

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AU - Perutz, Max F.

AU - Paoli, Massimo

AU - Lesk, Arthur M.

N1 - Funding Information: M.F.P. and A.M.L. thank the Wellcome Trust and M.P. thanks the Biological and Biotechnological Research Council for support.

PY - 1999/11

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N2 - Fix L, which contains a haemoglobin domain homologous to the PAS family and a histidine kinase complex that regulates expression of nitrogenase trigger stereochemical changes in and around the haem that, together with steric effects, control the activity of the kinase. Homology with the PAS family is based on a common core of about 20 structurally equivalent sites from which polar residues are excluded.

AB - Fix L, which contains a haemoglobin domain homologous to the PAS family and a histidine kinase complex that regulates expression of nitrogenase trigger stereochemical changes in and around the haem that, together with steric effects, control the activity of the kinase. Homology with the PAS family is based on a common core of about 20 structurally equivalent sites from which polar residues are excluded.

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Fix L, a haemoglobin that acts as an oxygen sensor: Signalling mechanism and structural basis of its homology with PAS domains

Abstract

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