TY - JOUR
T1 - FK 506 FOR LIVER, KIDNEY, AND PANCREAS TRANSPLANTATION
AU - Starzl, Thomas E.
AU - Fung, John
AU - Venkataramman, Raman
AU - Todo, Satoru
AU - Demetris, Anthony J.
AU - Jain, Ashok
N1 - Funding Information:
This work was supported by research grants from the Veterans Administration and project grant no DK 29961 from the National Institutes of Health.
PY - 1989/10/28
Y1 - 1989/10/28
N2 - FK 506 was given for immunosuppression in 14 liver recipients. The drug was used in the first 10 cases because the recipients under conventional immunosuppression had rejection, nephrotoxicity, or both. This salvage therapy was successful in 7 of the 10 attempts. 2 of the 10 patients in the original salvage group as well as 4 new patients underwent fresh orthotopic liver transplantation under FK 506 plus low-dose steroids from the outset. None of these 6 patients had rejection although 1 with preexisting cor pulmonale and coronary atherosclerosis died of a myocardial infarction. In addition, 2 of the 14 liver recipients were given cadaveric kidneys, either from the same donor or from a different donor, and a third was given a pancreas as well as a kidney from the liver donor. There were no rejections of the kidney and pancreas grafts, and serious side-effects were not encountered.
AB - FK 506 was given for immunosuppression in 14 liver recipients. The drug was used in the first 10 cases because the recipients under conventional immunosuppression had rejection, nephrotoxicity, or both. This salvage therapy was successful in 7 of the 10 attempts. 2 of the 10 patients in the original salvage group as well as 4 new patients underwent fresh orthotopic liver transplantation under FK 506 plus low-dose steroids from the outset. None of these 6 patients had rejection although 1 with preexisting cor pulmonale and coronary atherosclerosis died of a myocardial infarction. In addition, 2 of the 14 liver recipients were given cadaveric kidneys, either from the same donor or from a different donor, and a third was given a pancreas as well as a kidney from the liver donor. There were no rejections of the kidney and pancreas grafts, and serious side-effects were not encountered.
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U2 - 10.1016/S0140-6736(89)91014-3
DO - 10.1016/S0140-6736(89)91014-3
M3 - Article
C2 - 2478846
AN - SCOPUS:0024419167
SN - 0140-6736
VL - 334
SP - 1000
EP - 1004
JO - The Lancet
JF - The Lancet
IS - 8670
ER -