Flt3 ligand

M. L. Capitano; S. Zhang; H. E. Broxmeyer

doi:10.1016/B978-0-12-809324-5.03249-1

Flt3 ligand

M. L. Capitano, S. Zhang, H. E. Broxmeyer

Department of Physical Medicine and Rehabilitation

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Flt3 ligand (FL) is a transmembrane protein that binds to Flt3, a fms-like tyrosine kinase three receptor, and triggers the intracellular signaling cascade that leads to the proliferation and development of hematopoietic stem cells and progenitor cells as well as the development of the immune system. For most activities, FL has modest effects by itself; however, FL manifests potent co-stimulating activity and actively synergizes with other cytokines for optimal biological effects.

Original language	English (US)
Title of host publication	The Curated Reference Collection in Neuroscience and Biobehavioral Psychology
Publisher	Elsevier Science Ltd.
Pages	637-644
Number of pages	8
ISBN (Electronic)	9780128093245
DOIs	https://doi.org/10.1016/B978-0-12-809324-5.03249-1
State	Published - Jan 1 2016

All Science Journal Classification (ASJC) codes

General Medicine

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10.1016/B978-0-12-809324-5.03249-1

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abstract = "Flt3 ligand (FL) is a transmembrane protein that binds to Flt3, a fms-like tyrosine kinase three receptor, and triggers the intracellular signaling cascade that leads to the proliferation and development of hematopoietic stem cells and progenitor cells as well as the development of the immune system. For most activities, FL has modest effects by itself; however, FL manifests potent co-stimulating activity and actively synergizes with other cytokines for optimal biological effects.",

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AB - Flt3 ligand (FL) is a transmembrane protein that binds to Flt3, a fms-like tyrosine kinase three receptor, and triggers the intracellular signaling cascade that leads to the proliferation and development of hematopoietic stem cells and progenitor cells as well as the development of the immune system. For most activities, FL has modest effects by itself; however, FL manifests potent co-stimulating activity and actively synergizes with other cytokines for optimal biological effects.

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ER -

Flt3 ligand

Abstract

All Science Journal Classification (ASJC) codes

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