Forcing the ribosome to change its message

Sarah E. Leininger, Carol Deutsch, Edward P. O’Brien

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Mechanical forces can be generated when nascent protein segments are integrated into a membrane. These forces are then transmitted through the nascent protein to the ribosome’s catalytic core, but only a few biological consequences of this process have been identified to date. In this issue, Harrington et al. present evidence that these forces form a conserved mechanism to influence the efficiency of ribosomal frameshifting during translation of viral RNA, indicating that mechanical forces may play a broader regulatory role in translation than previously appreciated.

Original languageEnglish (US)
Pages (from-to)6809-6810
Number of pages2
JournalJournal of Biological Chemistry
Issue number20
StatePublished - May 15 2020

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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