Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork

Katherine N. Choe; George Lucian Moldovan

doi:10.1016/j.molcel.2016.12.020

Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork

Katherine N. Choe, George Lucian Moldovan

Research output: Contribution to journal › Review article › peer-review

221 Scopus citations

Abstract

Proliferating cell nuclear antigen (PCNA) lies at the center of the faithful duplication of eukaryotic genomes. With its distinctive doughnut-shaped molecular structure, PCNA was originally studied for its role in stimulating DNA polymerases. However, we now know that PCNA does much more than promote processive DNA synthesis. Because of the complexity of the events involved, cellular DNA replication poses major threats to genomic integrity. Whatever predicament lies ahead for the replication fork, PCNA is there to orchestrate the events necessary to handle it. Through its many protein interactions and various post-translational modifications, PCNA has far-reaching impacts on a myriad of cellular functions.

Original language	English (US)
Pages (from-to)	380-392
Number of pages	13
Journal	Molecular cell
Volume	65
Issue number	3
DOIs	https://doi.org/10.1016/j.molcel.2016.12.020
State	Published - Feb 2 2017

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

Access to Document

10.1016/j.molcel.2016.12.020

Cite this

@article{9fd0317fca3d4d0cbebcab5647b3b148,

title = "Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork",

abstract = "Proliferating cell nuclear antigen (PCNA) lies at the center of the faithful duplication of eukaryotic genomes. With its distinctive doughnut-shaped molecular structure, PCNA was originally studied for its role in stimulating DNA polymerases. However, we now know that PCNA does much more than promote processive DNA synthesis. Because of the complexity of the events involved, cellular DNA replication poses major threats to genomic integrity. Whatever predicament lies ahead for the replication fork, PCNA is there to orchestrate the events necessary to handle it. Through its many protein interactions and various post-translational modifications, PCNA has far-reaching impacts on a myriad of cellular functions.",

author = "Choe, {Katherine N.} and Moldovan, {George Lucian}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2017",

month = feb,

day = "2",

doi = "10.1016/j.molcel.2016.12.020",

language = "English (US)",

volume = "65",

pages = "380--392",

journal = "Molecular cell",

issn = "1097-2765",

publisher = "Cell Press",

number = "3",

}

TY - JOUR

T1 - Forging Ahead through Darkness

T2 - PCNA, Still the Principal Conductor at the Replication Fork

AU - Choe, Katherine N.

AU - Moldovan, George Lucian

PY - 2017/2/2

Y1 - 2017/2/2

N2 - Proliferating cell nuclear antigen (PCNA) lies at the center of the faithful duplication of eukaryotic genomes. With its distinctive doughnut-shaped molecular structure, PCNA was originally studied for its role in stimulating DNA polymerases. However, we now know that PCNA does much more than promote processive DNA synthesis. Because of the complexity of the events involved, cellular DNA replication poses major threats to genomic integrity. Whatever predicament lies ahead for the replication fork, PCNA is there to orchestrate the events necessary to handle it. Through its many protein interactions and various post-translational modifications, PCNA has far-reaching impacts on a myriad of cellular functions.

AB - Proliferating cell nuclear antigen (PCNA) lies at the center of the faithful duplication of eukaryotic genomes. With its distinctive doughnut-shaped molecular structure, PCNA was originally studied for its role in stimulating DNA polymerases. However, we now know that PCNA does much more than promote processive DNA synthesis. Because of the complexity of the events involved, cellular DNA replication poses major threats to genomic integrity. Whatever predicament lies ahead for the replication fork, PCNA is there to orchestrate the events necessary to handle it. Through its many protein interactions and various post-translational modifications, PCNA has far-reaching impacts on a myriad of cellular functions.

UR - http://www.scopus.com/inward/record.url?scp=85011286656&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85011286656&partnerID=8YFLogxK

U2 - 10.1016/j.molcel.2016.12.020

DO - 10.1016/j.molcel.2016.12.020

M3 - Review article

C2 - 28157503

AN - SCOPUS:85011286656

SN - 1097-2765

VL - 65

SP - 380

EP - 392

JO - Molecular cell

JF - Molecular cell

IS - 3

ER -

Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this