Fouling behavior of zwitterionic membranes: Impact of electrostatic and hydrophobic interactions

Mahsa Hadidi, Andrew L. Zydney

Research output: Contribution to journalArticlepeer-review

153 Scopus citations

Abstract

Several recent studies have demonstrated that zwitterionic surfaces are highly resistant to protein fouling due to their highly hydrated structure. The objective of this study was to develop a more fundamental understanding of the fouling behavior of zwitterionic ultrafiltration membranes compared to a series of charged and neutral membranes with nearly identical pore size. Membranes were generated by chemical modification of a cellulosic membrane using epichlorohydrin activation followed by reaction with ligands having approximately the same length but different end-group functionality. The extent of modification was evaluated by X-ray photoelectron spectroscopy (XPS), and the membrane surface characteristics were determined from streaming potential and contact angle measurements. Membrane fouling characteristics were studied under both static and dynamic filtration conditions using proteins with different size and isoelectric point. The extent of fouling was strongly affected by electrostatic and hydrophobic interactions between the protein and membrane. The zwitterionic membranes showed minimal protein adsorption and a very low degree of protein fouling over a wide range of conditions with all proteins, including conditions where the protein and membrane were oppositely charged. These results provide important insights into the low fouling characteristics of zwitterionic ultrafiltration membranes.

Original languageEnglish (US)
Pages (from-to)97-103
Number of pages7
JournalJournal of Membrane Science
Volume452
DOIs
StatePublished - Feb 15 2014

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • General Materials Science
  • Physical and Theoretical Chemistry
  • Filtration and Separation

Fingerprint

Dive into the research topics of 'Fouling behavior of zwitterionic membranes: Impact of electrostatic and hydrophobic interactions'. Together they form a unique fingerprint.

Cite this