Fragrance contact dermatitis: A worldwide multicenter investigation (Part II)

Walter Larsen, Hideo Nakayama, Torkil Fischer, Peter Elsner, Peter Frosch, Desmond Burrows, William Jordan, Stephanie Shaw, John Wilkinson, James Marks, M. Sugawara, Marc Nethercott, James Nethercott

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


The purpose of this study was to determine the frequency of responses to selected fragrance materials in patients who were fragrance sensitive. 178 patients were evaluated in 8 centers worldwide with a fragrance mix (FM) and 20 other fragrance materials. Reaction to the fragrance mixture (FM) occurred in 78.7% of the subjects. Substances reacting at a rate of 2% or higher included jasmine absolute, geranium oil bourbon, 1-citronellol, spearmint oil, 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-γ-2-benzopyran, omega-6-hexadecenlactone, dimethyltetrahydrobenzaldehyde (isomer mixture), and α-amylcinnamaldehyde. These chemicals should be furthur evaluated to corroborate their allergenicity. We are constantly looking for new fragrance allergens to extend the diagnostic capability of the fragrance mix (FM).

Original languageEnglish (US)
Pages (from-to)344-346
Number of pages3
JournalContact Dermatitis
Issue number6
StatePublished - 2001

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Dermatology


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