Fragrance contact dermatitis - A worldwide multicenter investigation (Part III)

Walter Larsen, Hideo Nakayama, Torkil Fischer, Peter Elsner, Peter Frosch, Desmond Burrows, William Jordan, Stephanie Shaw, John Wilkinson, James Marks, M. Sugawara, Marc Nethercott, James Nethercott

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


The purpose of this study was to determine the frequency of responses to selected fragrance materials in patients who were fragrance sensitive. 218 fragrance sensitive subjects were evaluated in eight centres worldwide with a fragrance mixture (FM) and 17 less well-studied fragrance materials. Reaction to the fragrance mixture (FM) occurred in 76% of the subjects. The (FM) detected all reactions to nerol and hydroxycitronellol and 93% of the reactions to clove bud oil. Ten fragrance materials were not detected by the FM and deserve further study: benzenepropanol, beta, beta, 3-trimethyl, hexyl-salicylate, DL-citronellol, synthetic ylang ylang oil, benzyl mixture, cyclohexyl-acetate, eugenyl methyl ether, isoeugenyl methyl ether, 3-phenyl-1-propanol, and 3, 7-dimethyl-7-methoxyoctan-2-ol.

Original languageEnglish (US)
Pages (from-to)141-144
Number of pages4
JournalContact Dermatitis
Issue number3
StatePublished - 2002

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Dermatology


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