Abstract
The concept is developed that enzyme mechanisms should be viewed as "catalytic networks" with multiple conformations that occur serially and in parallel in the mechanism. These coupled ensembles of conformations require a multi-dimensional standard free-energy surface that is very "rugged", containing multiple minima and transition states. Experimental and theoretical evidence is presented to support this concept.
Original language | English (US) |
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Pages (from-to) | 3317-3321 |
Number of pages | 5 |
Journal | Biochemistry |
Volume | 47 |
Issue number | 11 |
DOIs | |
State | Published - Mar 18 2008 |
All Science Journal Classification (ASJC) codes
- Biochemistry