From Natural Sources to Synthetic Derivatives: The Allyl Motif as a Powerful Tool for Fragment-Based Design in Cancer Treatment

Nora Astrain-Redin, Carmen Sanmartin, Arun K. Sharma, Daniel Plano

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Since the beginning of history, natural products have been an abundant source of bioactive molecules for the treatment of different diseases, including cancer. Many allyl derivatives, which have shown anticancer activity both in vitro and in vivo in a large number of cancers, are bioactive molecules found in garlic, cinnamon, nutmeg, or mustard. In addition, synthetic products containing allyl fragments have been developed showing potent anticancer properties. Of particular note is the allyl derivative 17-AAG, which has been evaluated in Phase I and Phase II/III clinical trials for the treatment of multiple myeloma, metastatic melanoma, renal cancer, and breast cancer. In this Perspective, we compile extensive literature evidence with descriptions and discussions of the most recent advances in different natural and synthetic allyl derivatives that could generate cancer drug candidates in the near future.

Original languageEnglish (US)
Pages (from-to)3703-3731
Number of pages29
JournalJournal of Medicinal Chemistry
Issue number6
StatePublished - Mar 23 2023

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery

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