From nutritional immunology to drug development

Meghna Verma, Raquel Hontecillas, Vida Abedi, Andrew Leber, Pinyi Lu, Nuria Tubau-Juni, Josep Bassaganya-Riera

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The chapter focuses on the key aspects of nutritional immunology that help accelerate the path to safer and more effective treatments. We review the complex network of interactions between diet, immune system, gut microbiome, and metabolism. We exemplify how advanced computational technologies such as artificial intelligence (AI) and machine learning methods combined with preclinical and translational models aid the discovery of novel immunoregulatory pathways. Further, we highlight nutritional immunology concepts translated to the development of novel therapeutics in immune mediated diseases such as IBD. Finally, we show how advancements in the field of nutritional immunology can be used to enable the development of predictive, preventive, and personalized path to safer and more effective drugs.

Original languageEnglish (US)
Title of host publicationAccelerated Path to Cures
PublisherSpringer International Publishing
Pages41-56
Number of pages16
ISBN (Electronic)9783319732381
ISBN (Print)9783319732374
DOIs
StatePublished - Apr 25 2018

All Science Journal Classification (ASJC) codes

  • General Medicine
  • General Immunology and Microbiology
  • General Computer Science
  • General Agricultural and Biological Sciences
  • General Biochemistry, Genetics and Molecular Biology

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