Fructose-1,6-bisphosphatase, malate dehydrogenase, isocitrate lyase, phosphoenolpyruvate carboxykinase, glyceraldehyde-3-phosphate dehydrogenase, and cyclophilin a are secreted in Saccharomyces cerevisiae grown in low glucose

Bennett J. Giardina; Hui Ling Chiang

doi:10.4161/cib.27216

Fructose-1,6-bisphosphatase, malate dehydrogenase, isocitrate lyase, phosphoenolpyruvate carboxykinase, glyceraldehyde-3-phosphate dehydrogenase, and cyclophilin a are secreted in Saccharomyces cerevisiae grown in low glucose

Bennett J. Giardina
, Hui Ling Chiang

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Our previous studies demonstrated that the key gluconeogenic enzyme fructose-1,6-bisphosphatase is secreted when Saccharomyces cerevisiae are starved of glucose for a prolonged period of time. In this study, we showed that malate dehydrogenase, isocitrate lyase, phosphoenolpyruvate carboxykinase, glyceraldehyde-3-phosphate dehydrogenase, and cyclophilin A are also secreted in glucose-starved cells. Thus, both gluconeogenic and nongluconeogenic enzymes are secreted via the non-classical pathway.

Original language	English (US)
Article number	e27216
Journal	Communicative and Integrative Biology
Volume	6
Issue number	6
DOIs	https://doi.org/10.4161/cib.27216
State	Published - 2013

All Science Journal Classification (ASJC) codes

General Agricultural and Biological Sciences

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title = "Fructose-1,6-bisphosphatase, malate dehydrogenase, isocitrate lyase, phosphoenolpyruvate carboxykinase, glyceraldehyde-3-phosphate dehydrogenase, and cyclophilin a are secreted in Saccharomyces cerevisiae grown in low glucose",

abstract = "Our previous studies demonstrated that the key gluconeogenic enzyme fructose-1,6-bisphosphatase is secreted when Saccharomyces cerevisiae are starved of glucose for a prolonged period of time. In this study, we showed that malate dehydrogenase, isocitrate lyase, phosphoenolpyruvate carboxykinase, glyceraldehyde-3-phosphate dehydrogenase, and cyclophilin A are also secreted in glucose-starved cells. Thus, both gluconeogenic and nongluconeogenic enzymes are secreted via the non-classical pathway.",

author = "Giardina, \{Bennett J.\} and Chiang, \{Hui Ling\}",

note = "Funding Information: Immuno-TEM was performed using the EM Core Facility at Penn State College of Medicine. This work was supported by Penn State Bridge Fund to Hui-Ling Chiang.",

year = "2013",

doi = "10.4161/cib.27216",

language = "English (US)",

volume = "6",

journal = "Communicative and Integrative Biology",

issn = "1942-0889",

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Fructose-1,6-bisphosphatase, malate dehydrogenase, isocitrate lyase, phosphoenolpyruvate carboxykinase, glyceraldehyde-3-phosphate dehydrogenase, and cyclophilin a are secreted in Saccharomyces cerevisiae grown in low glucose. / Giardina, Bennett J.; Chiang, Hui Ling.
In: Communicative and Integrative Biology, Vol. 6, No. 6, e27216, 2013.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Fructose-1,6-bisphosphatase, malate dehydrogenase, isocitrate lyase, phosphoenolpyruvate carboxykinase, glyceraldehyde-3-phosphate dehydrogenase, and cyclophilin a are secreted in Saccharomyces cerevisiae grown in low glucose

AU - Giardina, Bennett J.

AU - Chiang, Hui Ling

N1 - Funding Information: Immuno-TEM was performed using the EM Core Facility at Penn State College of Medicine. This work was supported by Penn State Bridge Fund to Hui-Ling Chiang.

PY - 2013

Y1 - 2013

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AB - Our previous studies demonstrated that the key gluconeogenic enzyme fructose-1,6-bisphosphatase is secreted when Saccharomyces cerevisiae are starved of glucose for a prolonged period of time. In this study, we showed that malate dehydrogenase, isocitrate lyase, phosphoenolpyruvate carboxykinase, glyceraldehyde-3-phosphate dehydrogenase, and cyclophilin A are also secreted in glucose-starved cells. Thus, both gluconeogenic and nongluconeogenic enzymes are secreted via the non-classical pathway.

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ER -

Fructose-1,6-bisphosphatase, malate dehydrogenase, isocitrate lyase, phosphoenolpyruvate carboxykinase, glyceraldehyde-3-phosphate dehydrogenase, and cyclophilin a are secreted in Saccharomyces cerevisiae grown in low glucose

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