FTY720 induces non-canonical phosphatidylserine externalization and cell death in acute myeloid leukemia

Keyphrases

• Cell Death 100%
• Acute Myeloid Leukemia 100%
• FTY720 100%
• Non-canonical 100%
• Induced Cell Death 25%
• Receptor Signaling 25%
• Sphingosine-1-phosphate Receptor (S1PR) 25%
• Cell Death Pathways 25%
• Phosphatidylserine Exposure 25%
• Immunosuppression 12%
• Reactive Oxygen Species 12%
• Anticancer Activity 12%
• Cytotoxicity 12%
• Mechanistic Insight 12%
• Multiple Sclerosis 12%
• Protein Phosphatase 2A (PP2A) 12%
• FDA-approved Drugs 12%
• Caspase-dependent Apoptosis 12%
• Fingolimod 12%
• Mechanistic Studies 12%
• Leukemia Cell Lines 12%
• Sphingosine Analogues 12%
• Endocytic Trafficking 12%
• Annexin V 12%
• Vacuolization 12%
• Non-canonical Pathway 12%
• Antitumor Properties 12%
• Regulated Cell Death 12%
• Ferroptosis 12%
• Acute Myeloid Leukemia Cells 12%
• Pyroptosis 12%
• Necroptosis 12%

Biochemistry, Genetics and Molecular Biology

• Cell Death 100%
• Myeloid 100%
• Phosphatidylserine 100%
• Sphingosine-1-Phosphate Receptor 28%
• Lipid 14%
• Cell Membrane 14%
• Anticancer 14%
• Sphingosine 14%
• Cytotoxicity 14%
• Caspase 14%
• Programmed Cell Death 14%
• Pyroptosis 14%
• Lipocortin 14%
• Necroptosis 14%
• Ferroptosis 14%

Pharmacology, Toxicology and Pharmaceutical Science

• Acute Myeloid Leukemia 100%
• Phosphatidylserine 100%
• Fingolimod 100%
• Sphingosine 1 Phosphate Receptor 22%
• Reactive Oxygen Metabolite 11%
• Sphingosine 11%
• Lipocortin 5 11%
• Caspase 11%
• Multiple Sclerosis 11%
• Ferroptosis 11%
• Cytotoxicity 11%
• Pyroptosis 11%