TY - JOUR
T1 - Functional alignment with anatomical networks is associated with cognitive flexibility
AU - Medaglia, John D.
AU - Huang, Weiyu
AU - Karuza, Elisabeth A.
AU - Kelkar, Apoorva
AU - Thompson-Schill, Sharon L.
AU - Ribeiro, Alejandro
AU - Bassett, Danielle S.
N1 - Publisher Copyright:
© 2017 The Author(s).
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Cognitive flexibility describes the human ability to switch between modes of mental function to achieve goals. Mental switching is accompanied by transient changes in brain activity, which must occur atop an anatomical architecture that bridges disparate cortical and subcortical regions via underlying white matter tracts. However, an integrated understanding of how white matter networks might constrain brain dynamics during cognitive processes requiring flexibility has remained elusive. Here, to address this challenge, we applied emerging tools from graph signal processing to examine whether blood oxygen level-dependent signals measured at each point in time correspond to complex underlying anatomical networks in 28 individuals performing a perceptual task that probed cognitive flexibility. We found that the alignment between functional signals and the architecture of the underlying white matter network was associated with greater cognitive flexibility across subjects. By computing a concise measure using multi-modal neuroimaging data, we uncovered an integrated structure-function relation of human behaviour.
AB - Cognitive flexibility describes the human ability to switch between modes of mental function to achieve goals. Mental switching is accompanied by transient changes in brain activity, which must occur atop an anatomical architecture that bridges disparate cortical and subcortical regions via underlying white matter tracts. However, an integrated understanding of how white matter networks might constrain brain dynamics during cognitive processes requiring flexibility has remained elusive. Here, to address this challenge, we applied emerging tools from graph signal processing to examine whether blood oxygen level-dependent signals measured at each point in time correspond to complex underlying anatomical networks in 28 individuals performing a perceptual task that probed cognitive flexibility. We found that the alignment between functional signals and the architecture of the underlying white matter network was associated with greater cognitive flexibility across subjects. By computing a concise measure using multi-modal neuroimaging data, we uncovered an integrated structure-function relation of human behaviour.
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U2 - 10.1038/s41562-017-0260-9
DO - 10.1038/s41562-017-0260-9
M3 - Article
C2 - 30498789
AN - SCOPUS:85042753812
SN - 2397-3374
VL - 2
SP - 156
EP - 164
JO - Nature Human Behaviour
JF - Nature Human Behaviour
IS - 2
ER -