TY - JOUR
T1 - Functional gait analysis in a spinal contusion rat model
AU - Bhimani, Abhiraj D.
AU - Kheirkhah, Pouyan
AU - Arnone, Gregory D.
AU - Nahhas, Cindy R.
AU - Kumar, Prateek
AU - Wonais, Matt
AU - Hidrogo, Hugo
AU - Aguilar, Eddy
AU - Spalinski, Daniel
AU - Gopalka, Mahie
AU - Roth, Steven
AU - Mehta, Ankit I.
N1 - Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/12
Y1 - 2017/12
N2 - Evaluating functional performance of spinal cord injury (SCI) rat models is essential for the development of novel treatments and breakthroughs. However, due to the variety of functional analysis methods available – each with its own strengths and weaknesses – it can be challenging to choose the most appropriate functional analysis test for the animal model. Therefore, we analyzed the strengths and weaknesses of five methods in order to determine which test is not only accurate and easily reproducible, but also relatively inexpensive so that it can be adopted universally. When comparing the Basso, Beattie, and Bresnahan (BBB) test, Ladder walking test, CatWalk test, Rotating Rod test, Microsoft Kinect system and VICON, we used the criteria of sensitivity, quality of data generated, statistical analysis of data, and rate of human error. These specific tests were chosen in order to compare the advantages and disadvantages of simple yet effective methods (BBB, Ladder test, and Rotating Rod test) to more complex and computerized methods (Catwalk, Microsoft Kinect and VICON).
AB - Evaluating functional performance of spinal cord injury (SCI) rat models is essential for the development of novel treatments and breakthroughs. However, due to the variety of functional analysis methods available – each with its own strengths and weaknesses – it can be challenging to choose the most appropriate functional analysis test for the animal model. Therefore, we analyzed the strengths and weaknesses of five methods in order to determine which test is not only accurate and easily reproducible, but also relatively inexpensive so that it can be adopted universally. When comparing the Basso, Beattie, and Bresnahan (BBB) test, Ladder walking test, CatWalk test, Rotating Rod test, Microsoft Kinect system and VICON, we used the criteria of sensitivity, quality of data generated, statistical analysis of data, and rate of human error. These specific tests were chosen in order to compare the advantages and disadvantages of simple yet effective methods (BBB, Ladder test, and Rotating Rod test) to more complex and computerized methods (Catwalk, Microsoft Kinect and VICON).
UR - http://www.scopus.com/inward/record.url?scp=85029211295&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85029211295&partnerID=8YFLogxK
U2 - 10.1016/j.neubiorev.2017.09.007
DO - 10.1016/j.neubiorev.2017.09.007
M3 - Review article
C2 - 28893554
AN - SCOPUS:85029211295
SN - 0149-7634
VL - 83
SP - 540
EP - 546
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
ER -