TY - JOUR
T1 - Functional mapping of drug response with pharmacodynamic-pharmacokinetic principles
AU - Ahn, Kwangmi
AU - Luo, Jiangtao
AU - Berg, Arthur
AU - Keefe, David
AU - Wu, Rongling
N1 - Funding Information:
We are grateful to Dr. Zuoheng Wang for analyzing the ACTG data using a bivariate functional mapping model. This work is supported by National Institute of Health American Recovery and Reinvestment Act (NIH ARRA) grant 09095.
PY - 2010/7
Y1 - 2010/7
N2 - Recent research in pharmacogenomics has inspired our hope to predict drug response by linking it with DNA information extracted from the human genome. However, many genetic models of drug response do not incorporate biochemical principles of host-drug interactions, limiting the effectiveness of the predictive models. We argue that functional mapping, a computational tool aimed at identifying genes and genetic networks that control dynamic traits, can help explain the detailed genetic architecture of drug response by incorporating pharmacokinetic and pharmacodynamic processes. Functional mapping is particularly powerful in determining the genetic commonality and differences of drug efficacy vs. drug toxicity and drug sensitivity vs. drug resistance. We pinpoint several future directions in which functional mapping can be coupled with systems biology to unravel the genetic and metabolic machinery of drug response.
AB - Recent research in pharmacogenomics has inspired our hope to predict drug response by linking it with DNA information extracted from the human genome. However, many genetic models of drug response do not incorporate biochemical principles of host-drug interactions, limiting the effectiveness of the predictive models. We argue that functional mapping, a computational tool aimed at identifying genes and genetic networks that control dynamic traits, can help explain the detailed genetic architecture of drug response by incorporating pharmacokinetic and pharmacodynamic processes. Functional mapping is particularly powerful in determining the genetic commonality and differences of drug efficacy vs. drug toxicity and drug sensitivity vs. drug resistance. We pinpoint several future directions in which functional mapping can be coupled with systems biology to unravel the genetic and metabolic machinery of drug response.
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U2 - 10.1016/j.tips.2010.04.004
DO - 10.1016/j.tips.2010.04.004
M3 - Article
C2 - 20488563
AN - SCOPUS:77954028167
SN - 0165-6147
VL - 31
SP - 306
EP - 311
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 7
ER -