TY - GEN
T1 - Functional, molecular and structural imaging using LED-based photoacoustic and ultrasound imaging system.
AU - Agrawal, Sumit
AU - Singh, Mithun Kuniyil Ajith
AU - Yang, Xinyi
AU - Albahrani, Hussain
AU - Dangi, Ajay
AU - Kothapalli, Sri Rajasekhar
N1 - Funding Information:
This project was partially funded by the NIH-NIBIB R00EB017729-04 (SRK) and Penn State Cancer Institute (SRK). We also acknowledge the support of NVIDIA Corporation with the donation of the Titan X Pascal GPU used for the reconstruction of LED-PAT images. We further thank CYBERDYNE Inc. for their technical support.
Publisher Copyright:
© 2020 SPIE.
PY - 2020
Y1 - 2020
N2 - Conventional photoacoustic imaging (PAI) systems use bulky and high-cost laser sources to derive functional and molecular information of the tissue. Recently, light emitting diodes (LED) have emerged as an affordable and compact alternative illumination source for PAI. Despite their low energies, LEDs have provided sufficient photoacoustic contrast for in vivo imaging of mice and for certain clinical applications. This is largely due to PA signal averaging allowed by higher repetition rates of the LEDs without compromising on video frame rate photoacoustic imaging. In this work, using multiple in vivo and phantom experiments, we demonstrate the potential of LED-based photoacoustic and ultrasound imaging (2-D and 3-D) for real-time functional, molecular and structural characterization of tissue. This includes photoacoustic derived functional oxygen saturation information and mapping molecules such as melanin, methylene blue and indocyanine green, and ultrasound derived anatomical information of tissue. These results demonstrate that LED-based PA and US imaging hold strong potential for accelerating several pre-clinical and clinical applications, especially in resource-poor settings.
AB - Conventional photoacoustic imaging (PAI) systems use bulky and high-cost laser sources to derive functional and molecular information of the tissue. Recently, light emitting diodes (LED) have emerged as an affordable and compact alternative illumination source for PAI. Despite their low energies, LEDs have provided sufficient photoacoustic contrast for in vivo imaging of mice and for certain clinical applications. This is largely due to PA signal averaging allowed by higher repetition rates of the LEDs without compromising on video frame rate photoacoustic imaging. In this work, using multiple in vivo and phantom experiments, we demonstrate the potential of LED-based photoacoustic and ultrasound imaging (2-D and 3-D) for real-time functional, molecular and structural characterization of tissue. This includes photoacoustic derived functional oxygen saturation information and mapping molecules such as melanin, methylene blue and indocyanine green, and ultrasound derived anatomical information of tissue. These results demonstrate that LED-based PA and US imaging hold strong potential for accelerating several pre-clinical and clinical applications, especially in resource-poor settings.
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U2 - 10.1117/12.2547048
DO - 10.1117/12.2547048
M3 - Conference contribution
AN - SCOPUS:85082708890
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Photons Plus Ultrasound
A2 - Oraevsky, Alexander A.
A2 - Wang, Lihong V.
PB - SPIE
T2 - Photons Plus Ultrasound: Imaging and Sensing 2020
Y2 - 2 February 2020 through 5 February 2020
ER -