Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase or AICAR Tfase

Dale L. Boger; Nancy Ellen Haynes; Mark S. Warren; Lata T. Gooljarsingh; Joseph Ramcharan; Paul A. Kitos; Stephen J. Benkovic

doi:10.1016/S0968-0896(97)00121-1

Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase or AICAR Tfase

Dale L. Boger
, Nancy Ellen Haynes
, Mark S. Warren
, Lata T. Gooljarsingh
, Joseph Ramcharan
, Paul A. Kitos
, Stephen J. Benkovic

Chemistry

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

A series of TDAF-based analogues of 10-formyl-tetrahydrofolic acid are examined in efforts to explore the formyl transfer region of GAR Tfase and AICAR Tfase.

Original language	English (US)
Pages (from-to)	1831-1838
Number of pages	8
Journal	Bioorganic and Medicinal Chemistry
Volume	5
Issue number	9
DOIs	https://doi.org/10.1016/S0968-0896(97)00121-1
State	Published - Sep 1997

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0968-0896(97)00121-1

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@article{c37cc167913d4543b537db1666074a1e,

title = "Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase or AICAR Tfase",

abstract = "A series of TDAF-based analogues of 10-formyl-tetrahydrofolic acid are examined in efforts to explore the formyl transfer region of GAR Tfase and AICAR Tfase.",

author = "Boger, \{Dale L.\} and Haynes, \{Nancy Ellen\} and Warren, \{Mark S.\} and Gooljarsingh, \{Lata T.\} and Joseph Ramcharan and Kitos, \{Paul A.\} and Benkovic, \{Stephen J.\}",

note = "Funding Information: We gratefullya cknowledgteh ef inanciasl upporto f the National Instituteso f Health (CA63536),T he Skaggs Institutef or ChemicalB iology,and the award of an ACS MedicinalC hemistryG raduateF ellowship( NEH, 1994-95) sponsoredb y Parke-DavisP harmaceutical Research.",

year = "1997",

month = sep,

doi = "10.1016/S0968-0896(97)00121-1",

language = "English (US)",

volume = "5",

pages = "1831--1838",

journal = "Bioorganic and Medicinal Chemistry",

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T1 - Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase or AICAR Tfase

AU - Boger, Dale L.

AU - Haynes, Nancy Ellen

AU - Warren, Mark S.

AU - Gooljarsingh, Lata T.

AU - Ramcharan, Joseph

AU - Kitos, Paul A.

AU - Benkovic, Stephen J.

N1 - Funding Information: We gratefullya cknowledgteh ef inanciasl upporto f the National Instituteso f Health (CA63536),T he Skaggs Institutef or ChemicalB iology,and the award of an ACS MedicinalC hemistryG raduateF ellowship( NEH, 1994-95) sponsoredb y Parke-DavisP harmaceutical Research.

PY - 1997/9

Y1 - 1997/9

N2 - A series of TDAF-based analogues of 10-formyl-tetrahydrofolic acid are examined in efforts to explore the formyl transfer region of GAR Tfase and AICAR Tfase.

AB - A series of TDAF-based analogues of 10-formyl-tetrahydrofolic acid are examined in efforts to explore the formyl transfer region of GAR Tfase and AICAR Tfase.

UR - https://www.scopus.com/pages/publications/0030767486

UR - https://www.scopus.com/pages/publications/0030767486#tab=citedBy

U2 - 10.1016/S0968-0896(97)00121-1

DO - 10.1016/S0968-0896(97)00121-1

M3 - Article

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AN - SCOPUS:0030767486

SN - 0968-0896

VL - 5

SP - 1831

EP - 1838

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 9

ER -

Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase or AICAR Tfase

Abstract

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