Abstract
Studies have been conducted on testing strategies for annulation of the two macrocyclic rings onto the central tricyclic nucleus of sarain A (1). In particular, methodology has been developed for introduction into the core of C-3' and C-3 substituents, which are necessary for construction of the 'eastern' and 'western' macrocyclic rings of 1, respectively. Formation of the western ring has been successfully addressed via a ring-closing olefin metathesis strategy utilizing the Grubbs ruthenium catalyst. With this macrocyclization approach, a key intermediate lactam has been prepared which will be utilized in a total synthesis of the natural product.
Original language | English (US) |
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Pages (from-to) | 587-595 |
Number of pages | 9 |
Journal | Journal of Organic Chemistry |
Volume | 64 |
Issue number | 2 |
DOIs | |
State | Published - Jan 22 1999 |
All Science Journal Classification (ASJC) codes
- Organic Chemistry