Further tolyporphins from the Blue-Green alga Tolypothrix nodosa.

Michèle R. Prinsep; Gregory M.L. Patterson; Linda K. Larsen; Charles D. Smith

doi:10.1016/0040-4020(95)00615-F

Further tolyporphins from the Blue-Green alga Tolypothrix nodosa.

Michèle R. Prinsep
, Gregory M.L. Patterson
, Linda K. Larsen
, Charles D. Smith

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Eight new porphinoids, tolyporphins B-I (2-9), along with the known tolyporphin A (1) have been isolated from a lipophilic extract of the Pacific cyanophyte, Tolypothrix nodosa. Their structures have been elucidated using 1- and 2-D NMR spectroscopic experiments and the tolyporphins showed varying activities in drug accumulation and competitive binding assays for multidrug resistance (MDR) reversal.

Original language	English (US)
Pages (from-to)	10523-10530
Number of pages	8
Journal	Tetrahedron
Volume	51
Issue number	38
DOIs	https://doi.org/10.1016/0040-4020(95)00615-F
State	Published - Sep 18 1995

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/0040-4020(95)00615-F

Cite this

@article{93707942ab8d46d289477a67f4b801e9,

title = "Further tolyporphins from the Blue-Green alga Tolypothrix nodosa.",

abstract = "Eight new porphinoids, tolyporphins B-I (2-9), along with the known tolyporphin A (1) have been isolated from a lipophilic extract of the Pacific cyanophyte, Tolypothrix nodosa. Their structures have been elucidated using 1- and 2-D NMR spectroscopic experiments and the tolyporphins showed varying activities in drug accumulation and competitive binding assays for multidrug resistance (MDR) reversal.",

author = "Prinsep, \{Mich{\`e}le R.\} and Patterson, \{Gregory M.L.\} and Larsen, \{Linda K.\} and Smith, \{Charles D.\}",

note = "Funding Information: This research was supported by NIH grants CA 12623 and 64983, the New Zealand-United States Cooperative Science Program, the Waikato-Bay of Plenty Branch of the Cancer Society of New Zealand, a University of Waikato Research Commitee Grant and a New Zealand Lotteries Science Grant. We thank Wesley Yoshida (University of Hawaii) for determining NMR spectra, Mike Burger (University of Hawaii), Bruce Clarke (University of Canterbury) and Michael Walker (University of Auckland) for determining mass spectra and Jack Zilfou (Fox Chase Cancer Center) for conducting anti-MDR assays. We thank the government of Pohnpei for granting permission to collect algae.",

year = "1995",

month = sep,

day = "18",

doi = "10.1016/0040-4020(95)00615-F",

language = "English (US)",

volume = "51",

pages = "10523--10530",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Ltd",

number = "38",

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TY - JOUR

T1 - Further tolyporphins from the Blue-Green alga Tolypothrix nodosa.

AU - Prinsep, Michèle R.

AU - Patterson, Gregory M.L.

AU - Larsen, Linda K.

AU - Smith, Charles D.

N1 - Funding Information: This research was supported by NIH grants CA 12623 and 64983, the New Zealand-United States Cooperative Science Program, the Waikato-Bay of Plenty Branch of the Cancer Society of New Zealand, a University of Waikato Research Commitee Grant and a New Zealand Lotteries Science Grant. We thank Wesley Yoshida (University of Hawaii) for determining NMR spectra, Mike Burger (University of Hawaii), Bruce Clarke (University of Canterbury) and Michael Walker (University of Auckland) for determining mass spectra and Jack Zilfou (Fox Chase Cancer Center) for conducting anti-MDR assays. We thank the government of Pohnpei for granting permission to collect algae.

PY - 1995/9/18

Y1 - 1995/9/18

N2 - Eight new porphinoids, tolyporphins B-I (2-9), along with the known tolyporphin A (1) have been isolated from a lipophilic extract of the Pacific cyanophyte, Tolypothrix nodosa. Their structures have been elucidated using 1- and 2-D NMR spectroscopic experiments and the tolyporphins showed varying activities in drug accumulation and competitive binding assays for multidrug resistance (MDR) reversal.

AB - Eight new porphinoids, tolyporphins B-I (2-9), along with the known tolyporphin A (1) have been isolated from a lipophilic extract of the Pacific cyanophyte, Tolypothrix nodosa. Their structures have been elucidated using 1- and 2-D NMR spectroscopic experiments and the tolyporphins showed varying activities in drug accumulation and competitive binding assays for multidrug resistance (MDR) reversal.

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U2 - 10.1016/0040-4020(95)00615-F

DO - 10.1016/0040-4020(95)00615-F

M3 - Article

AN - SCOPUS:0029091524

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SP - 10523

EP - 10530

JO - Tetrahedron

JF - Tetrahedron

IS - 38

ER -

Further tolyporphins from the Blue-Green alga Tolypothrix nodosa.

Abstract

All Science Journal Classification (ASJC) codes

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