Fusaric acid: A novel agent and mechanism to treat HNSCC

Brendan C. Stack; J. Paul Hansen; James M. Ruda; Jeff Jaglowski; Joseph Shvidler; Christopher S. Hollenbeak

doi:10.1016/j.otohns.2004.02.038

Fusaric acid: A novel agent and mechanism to treat HNSCC

Brendan C. Stack, J. Paul Hansen, James M. Ruda, Jeff Jaglowski, Joseph Shvidler, Christopher S. Hollenbeak

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Objective A new class of carboxylic acids has tumoricidal activity for head and neck squamous cell cancer (HNSCC). Fusaric acid (FA) can chelate divalent cations, especially zinc, and inactivate zinc finger proteins involved in DNA repair and protein synthesis. Methods 2 squamous carcinoma lines were utilized for in vitro and in vivo portions of this study. Cell counting and flow cytometry were used to analyze cells in culture in treatment and control groups over 96 hours. HNSCC subcutaneous implants were created in treatment and control groups of BALB-c nude mice (N = 30). Results In vitro studies demonstrated significant changes in cell numbers and cell cycle. In vivo studies of daily intralesional therapy for 1 month also showed reduced onset of growth and overall growth compared to controls. Conclusion FA appears to have a tumoristatic/tumoricidal effect on HNSCC. Further nude mice studies are needed to optimize dosing and administration regimens for FA in anticipation of clinical trials.

Original language	English (US)
Pages (from-to)	54-60
Number of pages	7
Journal	Otolaryngology - Head and Neck Surgery
Volume	131
Issue number	1
DOIs	https://doi.org/10.1016/j.otohns.2004.02.038
State	Published - Jul 2004

All Science Journal Classification (ASJC) codes

Surgery
Otorhinolaryngology

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10.1016/j.otohns.2004.02.038

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title = "Fusaric acid: A novel agent and mechanism to treat HNSCC",

abstract = "Objective A new class of carboxylic acids has tumoricidal activity for head and neck squamous cell cancer (HNSCC). Fusaric acid (FA) can chelate divalent cations, especially zinc, and inactivate zinc finger proteins involved in DNA repair and protein synthesis. Methods 2 squamous carcinoma lines were utilized for in vitro and in vivo portions of this study. Cell counting and flow cytometry were used to analyze cells in culture in treatment and control groups over 96 hours. HNSCC subcutaneous implants were created in treatment and control groups of BALB-c nude mice (N = 30). Results In vitro studies demonstrated significant changes in cell numbers and cell cycle. In vivo studies of daily intralesional therapy for 1 month also showed reduced onset of growth and overall growth compared to controls. Conclusion FA appears to have a tumoristatic/tumoricidal effect on HNSCC. Further nude mice studies are needed to optimize dosing and administration regimens for FA in anticipation of clinical trials.",

author = "Stack, {Brendan C.} and Hansen, {J. Paul} and Ruda, {James M.} and Jeff Jaglowski and Joseph Shvidler and Hollenbeak, {Christopher S.}",

year = "2004",

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doi = "10.1016/j.otohns.2004.02.038",

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T1 - Fusaric acid

T2 - A novel agent and mechanism to treat HNSCC

AU - Stack, Brendan C.

AU - Hansen, J. Paul

AU - Ruda, James M.

AU - Jaglowski, Jeff

AU - Shvidler, Joseph

AU - Hollenbeak, Christopher S.

PY - 2004/7

Y1 - 2004/7

N2 - Objective A new class of carboxylic acids has tumoricidal activity for head and neck squamous cell cancer (HNSCC). Fusaric acid (FA) can chelate divalent cations, especially zinc, and inactivate zinc finger proteins involved in DNA repair and protein synthesis. Methods 2 squamous carcinoma lines were utilized for in vitro and in vivo portions of this study. Cell counting and flow cytometry were used to analyze cells in culture in treatment and control groups over 96 hours. HNSCC subcutaneous implants were created in treatment and control groups of BALB-c nude mice (N = 30). Results In vitro studies demonstrated significant changes in cell numbers and cell cycle. In vivo studies of daily intralesional therapy for 1 month also showed reduced onset of growth and overall growth compared to controls. Conclusion FA appears to have a tumoristatic/tumoricidal effect on HNSCC. Further nude mice studies are needed to optimize dosing and administration regimens for FA in anticipation of clinical trials.

AB - Objective A new class of carboxylic acids has tumoricidal activity for head and neck squamous cell cancer (HNSCC). Fusaric acid (FA) can chelate divalent cations, especially zinc, and inactivate zinc finger proteins involved in DNA repair and protein synthesis. Methods 2 squamous carcinoma lines were utilized for in vitro and in vivo portions of this study. Cell counting and flow cytometry were used to analyze cells in culture in treatment and control groups over 96 hours. HNSCC subcutaneous implants were created in treatment and control groups of BALB-c nude mice (N = 30). Results In vitro studies demonstrated significant changes in cell numbers and cell cycle. In vivo studies of daily intralesional therapy for 1 month also showed reduced onset of growth and overall growth compared to controls. Conclusion FA appears to have a tumoristatic/tumoricidal effect on HNSCC. Further nude mice studies are needed to optimize dosing and administration regimens for FA in anticipation of clinical trials.

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Fusaric acid: A novel agent and mechanism to treat HNSCC

Abstract

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