Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): Synthesis and initial structure-activity relationships

James Kempson; William J. Pitts; Joseph Barbosa; Junqing Guo; Omonike Omotoso; Andrew Watson; Karen Stebbins; Gary C. Starling; John H. Dodd; Joel C. Barrish; Raymond Felix; Karl Fischer

doi:10.1016/j.bmcl.2005.02.025

Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): Synthesis and initial structure-activity relationships

James Kempson, William J. Pitts, Joseph Barbosa, Junqing Guo, Omonike Omotoso, Andrew Watson, Karen Stebbins, Gary C. Starling, John H. Dodd, Joel C. Barrish, Raymond Felix, Karl Fischer

Chemistry

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42 Scopus citations

Abstract

A series of fused pyrimidine based inhibitors of PDE7 have been derived from an earlier screening lead 1. The synthesis, structure-activity relationships (SAR) and selectivity against several other PDE family members are described.

Original language	English (US)
Pages (from-to)	1829-1833
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	15
Issue number	7
DOIs	https://doi.org/10.1016/j.bmcl.2005.02.025
State	Published - Apr 1 2005

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2005.02.025

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Kempson, J., Pitts, W. J., Barbosa, J., Guo, J., Omotoso, O., Watson, A., Stebbins, K., Starling, G. C., Dodd, J. H., Barrish, J. C., Felix, R., & Fischer, K. (2005). Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): Synthesis and initial structure-activity relationships. Bioorganic and Medicinal Chemistry Letters, 15(7), 1829-1833. https://doi.org/10.1016/j.bmcl.2005.02.025

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abstract = "A series of fused pyrimidine based inhibitors of PDE7 have been derived from an earlier screening lead 1. The synthesis, structure-activity relationships (SAR) and selectivity against several other PDE family members are described.",

author = "James Kempson and Pitts, {William J.} and Joseph Barbosa and Junqing Guo and Omonike Omotoso and Andrew Watson and Karen Stebbins and Starling, {Gary C.} and Dodd, {John H.} and Barrish, {Joel C.} and Raymond Felix and Karl Fischer",

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Kempson, J, Pitts, WJ, Barbosa, J, Guo, J, Omotoso, O, Watson, A, Stebbins, K, Starling, GC, Dodd, JH, Barrish, JC, Felix, R & Fischer, K 2005, 'Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): Synthesis and initial structure-activity relationships', Bioorganic and Medicinal Chemistry Letters, vol. 15, no. 7, pp. 1829-1833. https://doi.org/10.1016/j.bmcl.2005.02.025

TY - JOUR

T1 - Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7)

T2 - Synthesis and initial structure-activity relationships

AU - Kempson, James

AU - Pitts, William J.

AU - Barbosa, Joseph

AU - Guo, Junqing

AU - Omotoso, Omonike

AU - Watson, Andrew

AU - Stebbins, Karen

AU - Starling, Gary C.

AU - Dodd, John H.

AU - Barrish, Joel C.

AU - Felix, Raymond

AU - Fischer, Karl

PY - 2005/4/1

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N2 - A series of fused pyrimidine based inhibitors of PDE7 have been derived from an earlier screening lead 1. The synthesis, structure-activity relationships (SAR) and selectivity against several other PDE family members are described.

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

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ER -

Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): Synthesis and initial structure-activity relationships

Abstract

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