Fv2 encodes a truncated form of the Stk receptor tyrosine kinase

Derek A. Persons, Robert F. Paulson, Melanie R. Loyd, Mark T. Herley, Sara M. Bodner, Alan Bernstein, Pamela H. Correll, Paul A. Ney

Research output: Contribution to journalArticlepeer-review

135 Scopus citations

Abstract

The Friend virus susceptibility 2 (Fv2) locus encodes a dominant host factor that confers susceptibility to Friend virus-induced erythroleukaemia in mice. We mapped Fv2 to a 1.0-Mb interval that also contained the gene (Ron) encoding the stem cell kinase receptor (Stk). A truncated form of Stk (Sf-stk), which was the most abundant form of Stk in Fv2-sensitive (Fv2(ss)) erythroid cells, was not expressed in Fv2 resistant (Fv2(rr)) cells. Enforced expression of Sf-stk conferred susceptibility to Friend disease, whereas targeted disruption of Ron caused resistance. We conclude that the Fv2 locus encodes Ron, and that a naturally expressed, truncated form of Stk confers susceptibility to Friend virus-induced erythroleukaemia.

Original languageEnglish (US)
Pages (from-to)159-165
Number of pages7
JournalNature Genetics
Volume23
Issue number2
DOIs
StatePublished - Oct 1999

All Science Journal Classification (ASJC) codes

  • Genetics

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