Fv2 encodes a truncated form of the Stk receptor tyrosine kinase

Derek A. Persons; Robert F. Paulson; Melanie R. Loyd; Mark T. Herley; Sara M. Bodner; Alan Bernstein; Pamela H. Correll; Paul A. Ney

doi:10.1038/13787

Fv2 encodes a truncated form of the Stk receptor tyrosine kinase

Derek A. Persons
, Robert F. Paulson
, Melanie R. Loyd
, Mark T. Herley
, Sara M. Bodner
, Alan Bernstein
, Pamela H. Correll
, Paul A. Ney

Research output: Contribution to journal › Article › peer-review

137 Scopus citations

Abstract

The Friend virus susceptibility 2 (Fv2) locus encodes a dominant host factor that confers susceptibility to Friend virus-induced erythroleukaemia in mice. We mapped Fv2 to a 1.0-Mb interval that also contained the gene (Ron) encoding the stem cell kinase receptor (Stk). A truncated form of Stk (Sf-stk), which was the most abundant form of Stk in Fv2-sensitive (Fv2(ss)) erythroid cells, was not expressed in Fv2 resistant (Fv2(rr)) cells. Enforced expression of Sf-stk conferred susceptibility to Friend disease, whereas targeted disruption of Ron caused resistance. We conclude that the Fv2 locus encodes Ron, and that a naturally expressed, truncated form of Stk confers susceptibility to Friend virus-induced erythroleukaemia.

Original language	English (US)
Pages (from-to)	159-165
Number of pages	7
Journal	Nature Genetics
Volume	23
Issue number	2
DOIs	https://doi.org/10.1038/13787
State	Published - Oct 1999

All Science Journal Classification (ASJC) codes

Genetics

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10.1038/13787

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@article{48dc76a2f9174aa4a6535e5d16380ee3,

title = "Fv2 encodes a truncated form of the Stk receptor tyrosine kinase",

abstract = "The Friend virus susceptibility 2 (Fv2) locus encodes a dominant host factor that confers susceptibility to Friend virus-induced erythroleukaemia in mice. We mapped Fv2 to a 1.0-Mb interval that also contained the gene (Ron) encoding the stem cell kinase receptor (Stk). A truncated form of Stk (Sf-stk), which was the most abundant form of Stk in Fv2-sensitive (Fv2(ss)) erythroid cells, was not expressed in Fv2 resistant (Fv2(rr)) cells. Enforced expression of Sf-stk conferred susceptibility to Friend disease, whereas targeted disruption of Ron caused resistance. We conclude that the Fv2 locus encodes Ron, and that a naturally expressed, truncated form of Stk confers susceptibility to Friend virus-induced erythroleukaemia.",

author = "Persons, \{Derek A.\} and Paulson, \{Robert F.\} and Loyd, \{Melanie R.\} and Herley, \{Mark T.\} and Bodner, \{Sara M.\} and Alan Bernstein and Correll, \{Pamela H.\} and Ney, \{Paul A.\}",

note = "Funding Information: M. Hayman for reviewing the manuscript; and A. Nienhuis and G. Grosveld for additional support. This work was supported by NIH Cancer Center Support Grant No. P30 CA21765, the American Lebanese Syrian Associated Charities (ALSAC), an American Society of Hematology Junior Faculty Scholarship Award to P.H.C. and a Terry Fox Program Project Grant from the National Cancer Institute of Canada to A.B.",

year = "1999",

month = oct,

doi = "10.1038/13787",

language = "English (US)",

volume = "23",

pages = "159--165",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

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T1 - Fv2 encodes a truncated form of the Stk receptor tyrosine kinase

AU - Persons, Derek A.

AU - Paulson, Robert F.

AU - Loyd, Melanie R.

AU - Herley, Mark T.

AU - Bodner, Sara M.

AU - Bernstein, Alan

AU - Correll, Pamela H.

AU - Ney, Paul A.

N1 - Funding Information: M. Hayman for reviewing the manuscript; and A. Nienhuis and G. Grosveld for additional support. This work was supported by NIH Cancer Center Support Grant No. P30 CA21765, the American Lebanese Syrian Associated Charities (ALSAC), an American Society of Hematology Junior Faculty Scholarship Award to P.H.C. and a Terry Fox Program Project Grant from the National Cancer Institute of Canada to A.B.

PY - 1999/10

Y1 - 1999/10

N2 - The Friend virus susceptibility 2 (Fv2) locus encodes a dominant host factor that confers susceptibility to Friend virus-induced erythroleukaemia in mice. We mapped Fv2 to a 1.0-Mb interval that also contained the gene (Ron) encoding the stem cell kinase receptor (Stk). A truncated form of Stk (Sf-stk), which was the most abundant form of Stk in Fv2-sensitive (Fv2(ss)) erythroid cells, was not expressed in Fv2 resistant (Fv2(rr)) cells. Enforced expression of Sf-stk conferred susceptibility to Friend disease, whereas targeted disruption of Ron caused resistance. We conclude that the Fv2 locus encodes Ron, and that a naturally expressed, truncated form of Stk confers susceptibility to Friend virus-induced erythroleukaemia.

AB - The Friend virus susceptibility 2 (Fv2) locus encodes a dominant host factor that confers susceptibility to Friend virus-induced erythroleukaemia in mice. We mapped Fv2 to a 1.0-Mb interval that also contained the gene (Ron) encoding the stem cell kinase receptor (Stk). A truncated form of Stk (Sf-stk), which was the most abundant form of Stk in Fv2-sensitive (Fv2(ss)) erythroid cells, was not expressed in Fv2 resistant (Fv2(rr)) cells. Enforced expression of Sf-stk conferred susceptibility to Friend disease, whereas targeted disruption of Ron caused resistance. We conclude that the Fv2 locus encodes Ron, and that a naturally expressed, truncated form of Stk confers susceptibility to Friend virus-induced erythroleukaemia.

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DO - 10.1038/13787

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AN - SCOPUS:0032857069

SN - 1061-4036

VL - 23

SP - 159

EP - 165

JO - Nature Genetics

JF - Nature Genetics

IS - 2

ER -

Fv2 encodes a truncated form of the Stk receptor tyrosine kinase

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