GABA(A)-receptor assembly in vivo: Lessons from subunit mutant mice

H. Mohler; B. Luscher; J. M. Fritschy; D. Benke; J. Benson; U. Rudolph

doi:10.1016/S0024-3205(98)00116-7

GABA(A)-receptor assembly in vivo: Lessons from subunit mutant mice

H. Mohler, B. Luscher, J. M. Fritschy, D. Benke, J. Benson, U. Rudolph

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16 Scopus citations

Abstract

The rules governing the assembly of GABA(A) receptors in vivo were assessed in subunit mutant mice. The transcription of individual subunit genes was regulated independently. The lack of a particular subunit did not result in a molecular rescue by an enhanced transcription of other subunits. In addition, the availability of an α- and β-subunit was essential for receptor formation. Finally, highly selective recognition processes directed the subcellular targeting of receptors. The loss of a particular receptor subtype (α₅) did not lead to a subcellular redistribution of the remaining subtype (α2) present in the same cell.

Original language	English (US)
Pages (from-to)	1611-1615
Number of pages	5
Journal	Life Sciences
Volume	62
Issue number	17-18
DOIs	https://doi.org/10.1016/S0024-3205(98)00116-7
State	Published - Mar 27 1998

All Science Journal Classification (ASJC) codes

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/S0024-3205(98)00116-7

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abstract = "The rules governing the assembly of GABA(A) receptors in vivo were assessed in subunit mutant mice. The transcription of individual subunit genes was regulated independently. The lack of a particular subunit did not result in a molecular rescue by an enhanced transcription of other subunits. In addition, the availability of an α- and β-subunit was essential for receptor formation. Finally, highly selective recognition processes directed the subcellular targeting of receptors. The loss of a particular receptor subtype (α5) did not lead to a subcellular redistribution of the remaining subtype (α2) present in the same cell.",

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AU - Luscher, B.

AU - Fritschy, J. M.

AU - Benke, D.

AU - Benson, J.

AU - Rudolph, U.

PY - 1998/3/27

Y1 - 1998/3/27

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AB - The rules governing the assembly of GABA(A) receptors in vivo were assessed in subunit mutant mice. The transcription of individual subunit genes was regulated independently. The lack of a particular subunit did not result in a molecular rescue by an enhanced transcription of other subunits. In addition, the availability of an α- and β-subunit was essential for receptor formation. Finally, highly selective recognition processes directed the subcellular targeting of receptors. The loss of a particular receptor subtype (α5) did not lead to a subcellular redistribution of the remaining subtype (α2) present in the same cell.

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ER -

GABA(A)-receptor assembly in vivo: Lessons from subunit mutant mice

Abstract

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