Gadolinium-induced nephrogenic systemic fibrosis in a patient with an acute and transient kidney injury

R. E. Kalb, T. N. Helm, H. Sperry, C. Thakral, J. L. Abraham, E. Kanal

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Nephrogenic systemic fibrosis (NSF) describes a characteristic fibrosing disorder which typically presents with indurated plaques on the trunk and extremities of patients with advanced renal disease. We present a case of biopsy-confirmed NSF in a patient with severe acute kidney injury with no prior history of renal disease. A 64-year-old man with an acute and severe decrease in glomerular filtration rate underwent magnetic resonance imaging studies with gadolinium contrast (Omniscan™) and subsequently developed NSF. His renal disease had normalized at the time his skin disease developed. Skin biopsies revealed findings of NSF and scanning electron microscopy with energy-dispersive X-ray spectroscopy confirmed insoluble gadolinium within lesional tissue.

Original languageEnglish (US)
Pages (from-to)607-610
Number of pages4
JournalBritish Journal of Dermatology
Volume158
Issue number3
DOIs
StatePublished - Mar 2008

All Science Journal Classification (ASJC) codes

  • Dermatology

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